Results 81 to 90 of about 833,586 (386)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Sensorimotor processing for balance in spinocerebellar ataxia type 6. [PDF]
, 2015 We investigated whether balance impairments caused by cerebellar disease are associated with specific sensorimotor processing deficits that generalize across all sensory modalities.
Bunn, LM +4 more
core +1 more source
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Obtaining single stimulus evoked potentials with Wavelet Denoising [PDF]
Physica D, 2000; 145: 278-292, 2000 We present a method for the analysis of electroencephalograms (EEG). In particular, small signals due to stimulation, so called evoked potentials, have to be detected in the background EEG. This is achieved by using a denoising implementation based on the wavelet decomposition.
arxiv
Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]
, 2004 Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
A Frequency-Phase Potential for a Forced STNO Network: an Example of Evoked Memory [PDF]
arXiv, 2020 The network studied here is based on a standard model in physics, but it appears in various applications ranging from spintronics to neuroscience. When the network is forced by an external signal common to all its elements, there are shown to be two potential (gradient) functions: One for amplitudes and one for phases.
arxiv
N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. [PDF]
, 2015 Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of mGlu2/3 receptors by activating the glial ...
BATTAGLIA, Giuseppe +8 more
core +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
FEBS Open Bio, EarlyView.We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo +2 more
wiley +1 more source
Journal of Rehabilitation Medicine, 2021 Objective: To test whether the presence of N30 somatosensory evoked potentials, generated from the supplementary motor area and premotor cortex, correlate with post-stroke spasticity, motor deficits, or motor recovery stage.
Lilin Chen +8 more
doaj +1 more source