Results 231 to 240 of about 67,758 (305)

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun   +27 more
wiley   +1 more source

Corticospinal, reticulospinal and motoneuronal contributions to fatigability during a sustained contraction of the elbow flexors. [PDF]

open access: yesExp Physiol
Hayman O   +8 more
europepmc   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

open access: yesAdvanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou   +12 more
wiley   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

open access: yesAdvanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh   +7 more
wiley   +1 more source

Mu-Rhythm Phase Modulates Cortical Reactivity to Subthreshold TMS: A TMS-EEG Study. [PDF]

open access: yesBioengineering (Basel)
Zhao Y   +9 more
europepmc   +1 more source

On the role of descending drive and group III/IV muscle afferent feedback in modulating corticomotoneuronal excitability during knee-extensor exercise. [PDF]

open access: yesJ Physiol
Laginestra FG   +9 more
europepmc   +1 more source

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