Results 91 to 100 of about 66,829 (265)

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Ratiometric Mycotoxin Detection in Living Plants With Dual‐Emissive Nanosensors

Advanced Materials, EarlyView.
A minimally invasive microneedle patch integrates carbon dot‐embedded metal–organic frameworks as nanosensors to detect a key fungal toxin in living plants. The nanosensor produces a ratiometric fluorescence signal that enables early, non‐destructive diagnosis of fungal infection before visible symptoms, offering a new biomaterials‐based strategy for ...
Yuliang Li, Di Shen, Ziyang Huang, Suppanat Puangpathumanond, Calvin Thenarianto, Yue Zhao, Jolly Madathiparambil Saju, Rajani Sarojam, Dongmei Zhou, Tedrick Thomas Salim Lew   +9 more
wiley   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Desenvolvimento da acuidade visual de grades

Psicologia USP
Uma das funções visuais mais estudadas durante os primeiros anos de vida é a acuidade visual. A acuidade visual reflete a capacidade do sistema visual em discriminar detalhes de um objeto.
Solange Rios Salomão
doaj  

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Fixational eye movements and their associated evoked potentials during natural vision are altered in schizophrenia

Schizophrenia Research: Cognition
Background: Visual exploration is abnormal in schizophrenia; however, few studies have investigated the physiological responses during selecting objectives in more ecological scenarios.
Rocío Mayol-Troncoso, Pablo A. Gaspar, Roberto Verdugo, Juan J. Mariman, Pedro E. Maldonado   +4 more
doaj   +1 more source

Sonoenzymatically Triggered Cascading Degradation of Bioresorbable Materials for On‐Demand Transient Triboelectric Implants

Advanced Materials, EarlyView.
Our SEA strategy provides an efficient and biosafe approach for the on‐demand removal of implanted bioresorbable materials through cascading degradation that couples ultrasound‐triggered rapid mechanical disintegration with subsequent enzymatic degradation.
Jinsong Kim, Dong‐Min Lee, Youngwook Chung, Byung‐Joon Park, Hyeon Mo, Jong Won Seon, Han‐Yup Yum, Bosung Kim, Byung‐Ok Choi, Sang‐Woo Kim   +9 more
wiley   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

Boolean Logic‐Based Control Over Recombinant Protein Biomaterial Degradability and Therapeutic Delivery

Advanced Materials, EarlyView.
Fully recombinant protein‐based biomaterials execute complex Boolean logic for user‐programmable material degradation and concomitant therapeutic cargo release. Biologics, such as growth factors, can be incorporated within the crosslinkers as “drugamers”, while encapsulated cells can be released according to nested YES/OR/AND‐type logical operations ...
Murial L. Ross, Ryan Gharios, Shivani Kottantharayil, Cole A. DeForest   +3 more
wiley   +1 more source

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source