Results 191 to 200 of about 403,894 (280)

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

Advanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong, Xue Li, Le Wang, Qian Yang, Alix Tiran‐Cappello, Zhichao Liang, James Samsom, Quanying Liu, He Lin, Christelle Baunez, Fang Liu, Ti‐Fei Yuan   +11 more
wiley   +1 more source

Visual and Brainstem Auditory Evoked Potentials in Neurology [PDF]

, 2012
Ashraf Zaher
core   +2 more sources

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

Advanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang, Peng Qing, Qi Liu, Can Liu, Lei Liu, Xianyang Gan, Kun Fu, Chunmei Lan, Xinqi Zhou, Keith M. Kendrick, Benjamin Becker, Weihua Zhao   +11 more
wiley   +1 more source

Visual Evoked Potentials in the Great Apes [PDF]

, 1985
Berntson, Gary G., Boysen, Sarah T.
core   +1 more source

DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells

Advanced Science, EarlyView.
This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang, Ying Yang, Linlin Xu, Chaoju Hao, Jiaxiang Chen   +4 more
wiley   +1 more source

Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

Advanced Science, EarlyView.
Leukocytes sense mechanical cues provided by surrounding cells to regulate motility. Replicating the confining pressures applied by soft, elastic tissues in vitro is challenging. Here, the use of liquid‐liquid interfaces is introduced to model forces exerted by surrounding cells. Confining pressures are tunable by controlling interfacial curvature, and
Jonathan H. Schrope, Adam Horn, Kaitlyn Lazorchak, Clyde W. Tinnen, Jack J Stevens, Mehtab Farooqui, Tanner Robertson, Jiayi Li, David Bennin, Terry Juang, Adeel Ahmed, Chao Li, Anna Huttenlocher, David J Beebe   +13 more
wiley   +1 more source

Tumor‐Adhesive Chitosan‐Derived Multi‐Immune Agonist Unleashes Strong and Durable Anti‐Cancer Immunity

Advanced Science, EarlyView.
A tumor‐adhesive chitosan‐derived immune agonist TACTIC is developed for strong and durable anti‐tumor immunity. The immune agonist exhibits multi‐targets and modulates both tumor cell immunogenicity and pro‐inflammatory responses in immune cells, thereby potentiating the therapeutic efficacy of clinical radiotherapy.
Huilan He, Liang Liu, Yun Zheng, Jinlong Ji, Li Cao, Chunlian Ye, Yu Sun, Ying Zhang, Zhiyuan Zhong   +8 more
wiley   +1 more source

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source