Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Scientific ReportsIn El Mirador cave in Sierra de Atapuerca, Spain, a unique collection of human remains provides insights into cannibalistic practices from the Neolithic to the Bronze Age.
Palmira Saladié +13 more
doaj +1 more source
Big answers from small worlds: a user's guide for protist microcosms as a model system in ecology and evolution [PDF]
, 2014 Florian Altermatt +14 more
openalex +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Phosphatized multicellular algae in the Neoproterozoic Doushantuo Formation, China, and the early evolution of florideophyte red algae [PDF]
, 2004 Shuhai Xiao +3 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The evolution of betalain biosynthesis in Caryophyllales [PDF]
, 2019 Alfonso Timoneda +7 more
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
HSP90 as an evolutionary capacitor drives adaptive eye size reduction via atonal
Nature CommunicationsGenetic variation fuels evolution, and the release of cryptic variation is key for adaptation. The heat shock protein 90 (HSP90) has been proposed to act as an evolutionary capacitor by revealing such hidden variation under stress.
Rascha Sayed +8 more
doaj +1 more source
Language Evolution and Music Evolution
Together with language, music is perhaps the most distinctive behavioral trait of our species. Different hypotheses have been proposed to explain why only humans speak and why only they perform music and, if both abilities are evolutionary related, how and why they eventually diverged. Human linguisticality and musicality are certainly biologically and
Antonio Benítez-Burraco +1 more
openaire +1 more source