Results 121 to 130 of about 10,860,643 (378)
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Cultural replication and microbial evolution [PDF]
, 2014 The aim of this paper is to argue that cultural evolution is in many ways much more similar to microbial than to macrobial biological evolution.
Nanay, Bence
core
Evolution of twist-3 multi-parton correlation functions relevant to single transverse-spin asymmetry
, 2008 We constructed two sets of twist-3 correlation functions that are responsible for generating the novel single transverse-spin asymmetry in the QCD collinear factorization approach.
A. Bravar +9 more
core +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
The Evolution Concept: The Concept Evolution [PDF]
SSRN Electronic Journal, 2017 This is an epistemologically-driven history of the concept of evolution. Starting from its inception, this work will follow the development of this pregnant concept. However, in contradistinction to previous attempts, the objective will not be the identification of the different meanings it adopted through history, but conversely, it will let the ...
openaire +2 more sources
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
New England Journal of Medicine, 2012 BACKGROUND Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.
M. Gerlinger +30 more
semanticscholar +1 more source
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
Model evolution and system evolution
Journal of Computer Science and Technology, 2000 In this paper we define an evolution mechanism with formal semantics using the metamodeling methodology [Geisler et al.98] based on dynamic logic. A remarkable feature of the metamodeling methodology is the ability to define the relation of intentional and extensional entities within one level, allowing not only for the description of structural ...
Pons, Claudia +2 more
openaire +3 more sources
, 2014 We review chemical evolution models developed for M31 as well as the abundance determinations available for this galaxy. Then we present a recent chemical evolution model for M31 including radial gas flows and galactic fountains along the disk, as well ...
Matteucci, F., Spitoni, E.
core +1 more source