Results 121 to 130 of about 10,682,507 (345)

The Evolution of Earth Structure [PDF]

, 1904
Albert de Lapparent, E. Mellard Reade
openalex   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Repeated loss of function at HD mating-type genes and of recombination in anther-smut fungi

Nature Communications
Basidiomycete fungi typically have two mating-type loci controlling mating compatibility, HD and PR, residing on different chromosomes. Loss-of-function in mating compatibility has been reported at the PR genes in a few heterothallic basidiomycetes, but ...
Elise A. Lucotte, Paul Jay, Quentin Rougemont, Loreleï Boyer, Amandine Cornille, Alodie Snirc, Amandine Labat, Elizabeth Chahine, Marine Duhamel, Alice Namias, Jacob Gendelman, Wen-Juan Ma, Roxanne K. Hayes, Shikhi Baruri, Joseph P. Ham, Michael H. Perlin, Michael E. Hood, Ricardo C. Rodríguez de la Vega, Tatiana Giraud   +18 more
doaj   +1 more source

Factors in the Historical Evolution of Mexico [PDF]

, 1919
T. Esquivel Obregón
openalex   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

The coincidence of ecological opportunity with hybridization explains rapid adaptive radiation in Lake Mweru cichlid fishes

Nature Communications, 2019
Recent studies have suggested that hybridization can facilitate adaptive radiations. Here, the authors show that opportunity for hybridization differentiates Lake Mweru, where cichlids radiated, and Lake Bangweulu, where cichlids did not radiate despite ...
Joana I. Meier, Rike B. Stelkens, Domino A. Joyce, Salome Mwaiko, Numel Phiri, Ulrich K. Schliewen, Oliver M. Selz, Catherine E. Wagner, Cyprian Katongo, Ole Seehausen   +9 more
doaj   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Evidence of neolithic cannibalism among farming communities at El Mirador cave, Sierra de Atapuerca, Spain

Scientific Reports
In El Mirador cave in Sierra de Atapuerca, Spain, a unique collection of human remains provides insights into cannibalistic practices from the Neolithic to the Bronze Age.
Palmira Saladié, Francesc Marginedas, Juan Ignacio Morales, Josep María Vergès, Ethel Allué, Isabel Expósito, Marina Lozano, Patricia Martín, Javier Iglesias-Bexiga, Marta Fontanals, Roser Marsal, Raquel Hernando, Aitor Burguet-Coca, Antonio Rodríguez-Hidalgo   +13 more
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source