Results 131 to 140 of about 8,690,713 (332)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Evolution of defect structure of grossly nonstoichiometric Ca_1−xR_xF_2+xcrystals (R³⁺= La, Nd, Dy, Ho, Yb) [PDF]

, 1996
N. B. Grigorieva, L. P. Otroschenko, B. Maximov, Б. П. Соболев, V. I. Simonov   +4 more
openalex   +1 more source

Evolution of solar wind sources and coronal rotation driven by the cyclic variation of the Sun's large-scale magnetic field [PDF]

, 2023
Adam J. Finley, A. S. Brun
openalex   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Evidence of neolithic cannibalism among farming communities at El Mirador cave, Sierra de Atapuerca, Spain

Scientific Reports
In El Mirador cave in Sierra de Atapuerca, Spain, a unique collection of human remains provides insights into cannibalistic practices from the Neolithic to the Bronze Age.
Palmira Saladié, Francesc Marginedas, Juan Ignacio Morales, Josep María Vergès, Ethel Allué, Isabel Expósito, Marina Lozano, Patricia Martín, Javier Iglesias-Bexiga, Marta Fontanals, Roser Marsal, Raquel Hernando, Aitor Burguet-Coca, Antonio Rodríguez-Hidalgo   +13 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Differential and defective expression of Koala Retrovirus indicate complexity of host and virus evolution [PDF]

, 2017
Rachael Tarlinton, Alistair R. Legione, Nishat Sarker, J. Fabijan, J. Meers, Lee McMichael, G. C. Simmons, Helen Owen, Jennifer M. Seddon, Gregory J. Dick, James Ryder, F. Hemmatzedah, Darren J. Trott, Natasha Speight, Nadine Holmes, Matthew Loose, Richard D. Emes   +16 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

HSP90 as an evolutionary capacitor drives adaptive eye size reduction via atonal

Nature Communications
Genetic variation fuels evolution, and the release of cryptic variation is key for adaptation. The heat shock protein 90 (HSP90) has been proposed to act as an evolutionary capacitor by revealing such hidden variation under stress.
Rascha Sayed, Özge Şahin, Mohammed Errbii, Reshma R, Robert Peuß, Tobias Prüser, Lukas Schrader, Nora K. E. Schulz, Joachim Kurtz   +8 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source