Results 161 to 170 of about 2,325,018 (299)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The importance of epistasis in the evolution of viral pathogens. [PDF]

Virus Evol
Manivannan SN, Diaz Arenas C, Grubaugh ND, Ogbunugafor CB.   +3 more
europepmc   +1 more source

Can the experimental evolution programme help us elucidate the genetic basis of adaptation in nature? [PDF]

, 2015
Susan F. Bailey, Thomas Bataillon
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Early transitions in the evolution of cognition. [PDF]

Hist Philos Life Sci
Nejad Kourki A.
europepmc   +1 more source

Theory and Empiricism in Virulence Evolution

, 2014
James J. Bull, Adam S. Lauring
openalex   +2 more sources

Composition, Provenance, and Tectonic Setting of the Southern Kangurtag Accretionary Complex in the Eastern Tianshan, NW China: Implications for the Late Paleozoic Evolution of the North Tianshan Ocean [PDF]

, 2019
Zhenyu Chen, Wenjiao Xiao, Brian F. Windley, Karel Schulmann, Qigui Mao, Zhiyong Zhang, Ji’en Zhang, Chen Deng, Shuaihua Song   +8 more
openalex   +1 more source

Stellar migrations and metal flows – Chemical evolution of the thin disc of a simulated Milky Way analogous galaxy [PDF]

, 2020
Fiorenzo Vincenzo, Chiaki Kobayashi
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Analysis of the Evolution of Drought, Flood, and Drought-Flood Abrupt Alternation Events under Climate Change Using the Daily SWAP Index [PDF]

, 2020
Ying Zhao, Zhaohui Weng, Hua Chen, Jiawei Yang   +3 more
openalex   +1 more source