Results 181 to 190 of about 2,325,018 (299)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Attenuation of HIV severity by slightly deleterious mutations can explain the long-term trajectory of virulence evolution. [PDF]

PLoS Comput Biol
Longley H, Fraser C, Wymant C, Lythgoe K.   +3 more
europepmc   +1 more source

Spatiotemporal evolution of seismic and aseismic slip on the Longitudinal Valley Fault, Taiwan

, 2014
Marion Y. Thomas, Jean‐Philippe Avouac, Johann Champenois, Jian‐Cheng Lee, Long‐Chen Kuo   +4 more
openalex   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A novel hybridization of birds of prey-based optimization with differential evolution mutation and crossover for chaotic dynamics identification. [PDF]

Sci Rep
Ekinci S, Izci D, Kayri M, Elsayed F, Salman M.   +4 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Towards a Research Programme Aiming at Causes and Consequences of Reticulate Evolution. [PDF]

Biology (Basel)
Oberprieler C.
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Correction to: Experimental evidence of vaccine-driven evolution of porcine reproductive and respiratory syndrome virus type 2. [PDF]

Virus Evol
europepmc   +1 more source

Long-term adaptive laboratory evolution of Saccharomyces cerevisiae for high-titer lactic acid production at low pH. [PDF]

Microb Cell Fact
Altvater M, Tomico-Cuenca I, Mattanovich D, Sauer M.   +3 more
europepmc   +1 more source