Results 261 to 270 of about 4,368,379 (347)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

C3 glomerulonephritis with light chain crystalline podocytopathy and non-crystalline proximal tubulopathy: a case report and integrative clinicopathologic analysis. [PDF]

BMC Nephrol
Li J, Zhang Q, Zhou M, Tang L, Su X.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

<i>Bacillus thuringiensis</i> and insects: a century of intimate history. [PDF]

J Bacteriol
Slamti L, Lereclus D.
europepmc   +1 more source

Accretion of volatile elements on Earth without the need of a late veneer. [PDF]

Sci Adv
Calvo L, Siebert J, Huang D, Blanchard I, Kubik E, Bonino V, Schreiber A, Avice G, Labidi J.   +8 more
europepmc   +1 more source

Effect of Copper in Gas-Shielded Solid Wire on Microstructural Evolution and Cryogenic Toughness of X80 Pipeline Steel Welds. [PDF]

Materials (Basel)
Peng L, Hong R, Ma QL, Liu NS, Yin SB, Jia SJ.   +5 more
europepmc   +1 more source

Unveiling the Role of Graphite Morphology in Ductile Iron: A 3D FEM-Based Micromechanical Framework for Damage Evolution and Mechanical Performance Prediction with Applicability to Multiphase Alloys. [PDF]

Materials (Basel)
Tao J, Jiang Y, Xie S, Wang Y, Zhou Z, Fu L, Mao C, Li L, Huang J, Liu S.   +9 more
europepmc   +1 more source

Evolution inclusions in Hilbert spaces

openaire   +1 more source