Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Verification of temporal consistency constraints in the evolution of software for intelligent unmanned systems driven by model checking. [PDF]
Sci RepLu C, Li C, Liu C, Wu X, Huang Y.
europepmc +1 more source
The mass balance approach; application to interpreting the chemical evolution of hydrologic systems [PDF]
, 1980 L. Niel Plummer, Willem Back
openalex +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Why Is the Universe Not Frozen by the Quantum Zeno Effect? [PDF]
Entropy (Basel)Soulas A.
europepmc +1 more source
Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system. [PDF]
BMC Genomics, 2016 Kang L +4 more
europepmc +1 more source
The Origin and Early History of the Sun and the Planetary System in the Context of Stellar Evolution [PDF]
, 1983 G. H. Herbig
openalex +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source