Results 41 to 50 of about 2,270,763 (304)

Differential fates of Kazald gene quartet: Ancestral roles in skeletogenesis and regeneration to putative innovations in fish and birds

open access: yesiScience
Summary: Gene orthology inference across species is crucial to identify gains and losses of functions. The discovery in axolotl (Ambystoma mexicanum) of a regeneration-associated gene identified as either Kazald1 or Kazald2 led us to investigate its ...
Sean D. Keeley   +8 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko   +5 more
wiley   +1 more source

On Evolutionary Novelty

open access: yesBioCosmos
Darwin's ‘endless forms most beautiful’ was his testimony to the creative power of natural selection. Creativity, by definition, implies novelty: bringing into existence something which had never before existed. Novelty constitutes the grist for the mill
Turner J. Scott
doaj   +1 more source

A cetacean-specific CNE suppresses osteogenesis to drive appendicular modification in secondary aquatic adaptation

open access: yesiScience
Summary: Cetaceans represent a hallmark of secondary aquatic adaptation, accompanied by extensive appendicular remodeling, whose underlying regulatory mechanisms remain challenging to resolve.
Yao Liu   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Oncogenic stress alters predator-prey interactions between a globally invasive and a native planaria species

open access: yesiScience
Summary: Oncogenic pressures, factors that increase tumor risk, are intensifying with human-driven environmental change, yet their ecological effects remain mainly unquantified.
Antoine M. Dujon   +6 more
doaj   +1 more source

Environmental influence on Pristionchus pacificus mouth form through different culture methods

open access: yesScientific Reports, 2017
Environmental cues can impact development to elicit distinct phenotypes in the adult. The consequences of phenotypic plasticity can have profound effects on morphology, life cycle, and behavior to increase the fitness of the organism.
Michael S. Werner   +8 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A hypothesis in evolutionary biology

open access: yesCoRR, 2018
The classic Trivers-Willard hypothesis suggested the existence of means or conditions able to influence or control the sex of the offspring. Here I propose that mechanisms for the alteration of the gender of the offspring could possibly be formulated in terms of a distributed system of messages expressing a change in the environmental conditions.
openaire   +2 more sources

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