Results 41 to 50 of about 7,677,859 (208)
Self-adaptive GA, quantitative semantic similarity measures and ontology-based text clustering [PDF]
, 2008 As the common clustering algorithms use vector space model (VSM) to represent document, the conceptual relationships between related terms which do not co-occur literally are ignored.
Yu, Wei +3 more
core +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Investigating the Evolutionary Forces Acting on Mammalian Transcription Factor Binding [PDF]
, 2015 Transcription factors (TFs) transcriptionally regulate genes by binding nearby sequence elements. The evolutionary mechanisms driving the evolution of TF binding events between species are unclear.
Douglas, Gavin
core +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Study of Chemical Similarity Between Molecules Through a Comparative Method of Standard Thermodynamic Properties [PDF]
, 2018 Chemical similarity between molecules, is a key concept in drug design and drug discovery. The advance in computational science, had given rise to many new possibilities for understand difference and similarity between molecules.
Tetsafe, De Angeli +1 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Similarity Continua and Criteria in Memetic Theory and Analysis [PDF]
, 2014 The aim of this article is to schematize and quantify certain of the similarity relationships which are relevant to the application of memetics to music, in order to sketch a methodology by which evolutionarily significant resemblances (particularly in ...
Jan, Steven
core
Investigating Pharmacological Similarity by Charting Chemical Space
, 2015 In this study, biologically relevant areas of the chemical space were analyzed using ChemGPS-NP. This application enables comparing groups of ligands within a multidimensional space based on principle components derived from physicochemical descriptors ...
Buonfiglio, Rosa, +6 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Analysis of shape, properties and "druggability" of protein binding pockets [PDF]
, 2009 Kenntnisse über die dreidimensionale Struktur therapeutisch relevanter Zielproteine bieten wertvolle Informationen für den rationalen Wirkstoffentwurf.
Weisel, Martin
core