Results 81 to 90 of about 6,048,895 (335)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Revista Facultad de Ingeniería, 2020 Part-of-Speech Tagging (POST) is a complex task in the preprocessing of Natural Language Processing applications. Tagging has been tackled from statistical information and rule-based approaches, making use of a range of methods.
Miguel Alexis Solano-Jiménez +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Evolutionary Automata and Deep Evolutionary Computation
CoRREvolution by natural selection, which is one of the most compelling themes of modern science, brought forth evolutionary algorithms and evolutionary computation, applying mechanisms of evolution in nature to various problems solved by computers. In this paper we concentrate on evolutionary automata that constitute an analogous model of evolutionary ...
openaire +3 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Image sequence sorting algorithm for commercial tasks
Frontiers in Artificial IntelligenceIntroductionThe sorting of sequences of images is crucial for augmenting user engagement in various virtual commercial platforms, particularly within the real estate sector.
Guillaume Grelier +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Open Reading Frame Phylogenetic Analysis on the Cloud
International Journal of Genomics, 2013 Phylogenetic analysis has become essential in researching the evolutionary relationships between viruses. These relationships are depicted on phylogenetic trees, in which viruses are grouped based on sequence similarity.
Che-Lun Hung, Chun-Yuan Lin
doaj +1 more source
Sequential Minimax Search for Multi-Layer Gene Grouping
IEEE Access, 2019 Many areas of exploratory data analysis need to deal with high-dimensional data sets. Some real life data like human gene have an inherent structure of hierarchy, which embeds multi-layer feature groups.
Wenting Wang +3 more
doaj +1 more source