Results 121 to 130 of about 2,645,282 (301)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Inconspicuous breeding coloration to conceal eggs during mouthbrooding in male cardinalfish
iScienceSummary: Animals exhibit colorations optimal for their niche, which hides their existence from other organisms. In Apogoninae fishes, the father broods their egg inside their mouth.
Hikaru Ishihara, Shinji Kanda
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
iScienceSummary: Insect metamorphosis is a captivating aspect of animal research. To address the controversy regarding the developmental correspondence between hemimetabolous and holometabolous insects, we utilized non-destructive micro-computed tomography (CT ...
Hang Zhou +9 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Host defenses against bacterial pore-forming toxins [PDF]
, 2011 Pore-forming toxins (PFTs), the most common bacterial toxins, contribute to infection by perforating host cell membranes. Excessive use and lack of new development of antibiotics are causing increasing numbers of drug-resistant bacteria, like methicillin-
Sub Developmental Biology +2 more
core +2 more sources
Tracking in cell and developmental biology
, 2009 The past decade has seen an unprecedented data explosion in biology. It has become evident that in order to take full advantage of the potential wealth of information hidden in the data produced by even a single experiment, visual inspection and manual ...
Dzyubachyk, Oleh +4 more
core +1 more source
STAR ProtocolsSummary: Here, we present a protocol for digitizing envelope-preserved entomological museum specimens. We describe steps for acquiring images, transcribing labels into Darwin Core records, and validating taxonomy and geography.
Davide Tamagnini, Claudio Chimenti
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Biochemical analysis of the basic helix-loop-helix transcription factor Olig2 [PDF]
, 2014 The basic helix-loop-helix (bHLH) transcription factors oligodendrocyte transcription factor 1 (Olig1) and Olig2 are structurally similar and, to a first approximation, coordinately expressed in the developing CNS and postnatal brain.
Sub Developmental Biology +2 more
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