Results 111 to 120 of about 12,926 (256)

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Enhancing vaccination strategies for epidemic control through effective lockdown measures

Heliyon
Evolutionary epidemiology models have substantially impacted the study of various infections and prevention methods in the biology field. These models are called Susceptible, Lockdown, Vaccinated, Infected, and Recovered (SLVIR) epidemic dynamics.
Abhi Chakraborty, K.M. Ariful Kabir
doaj   +1 more source

Evolutionary game theory of continuous traits from a causal perspective. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Lehtonen J, Otsuka J.
europepmc   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Stackelberg evolutionary game theory: how to manage evolving systems. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Stein A, Salvioli M, Garjani H, Dubbeldam J, Viossat Y, Brown JS, Staňková K.   +6 more
europepmc   +1 more source

Chemically Gradient Ordered Nanodomains Enable Large Tensile Ductility in Gigapascal Lightweight Refractory High‐Entropy Alloys

Advanced Science, EarlyView.
A high‐strength lightweight refractory high‐entropy alloy achieves extraordinary ductility owing to the introduction of coherent chemically gradient ordered nanodomains (CGONs). The CGONs not only serve as effective barriers to dislocation motion (strengthening) but also significantly promote dislocation nucleation and multiplication (ductilizing) upon
Wei Zhang, Dingshun Yan, Yong Zhang, Zhiming Li   +3 more
wiley   +1 more source

Tripartite evolutionary game analysis of medical data governance: interactions among government, medical institutions, and third-party assessment agencies

Frontiers in Public Health
In the era of the digital economy, medical data has emerged as a core production factor, yet revitalizing its value and achieving effective governance remain critical challenges. Based on evolutionary game theory, this paper constructs a three-party game
Xingxian Liu, Jing Gong, Jusheng Liu
doaj   +1 more source

Evolutionary game theory and simulations based on doctor and patient medical malpractice under government regulation. [PDF]

Sci Rep, 2023
Song L, Yu Z, Fang J, He Q.
europepmc   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Evolutionary game theory and simulations based on doctor and patient medical malpractice. [PDF]

PLoS One, 2023
Song L, Yu Z, He Q.
europepmc   +1 more source