Results 61 to 70 of about 235,286 (321)

Optimizing Neural Architecture Search using Limited GPU Time in a Dynamic Search Space: A Gene Expression Programming Approach

open access: yes, 2020
Efficient identification of people and objects, segmentation of regions of interest and extraction of relevant data in images, texts, audios and videos are evolving considerably in these past years, which deep learning methods, combined with recent ...
Alves, Jeovane Honorio   +1 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Optimal sizing and placement of capacitors in the isolated microgrid throughout the day considering the demand response program

open access: yesFrontiers in Energy Research
Reactive power compensation (RPC) is a big problem during power system operation. Parenthetically, capacitor allocation and sizing may be the only convenient solution for RPC of power systems. The loss sensitivity factor (LSF) is applied here for finding
Mousumi Basu   +5 more
doaj   +1 more source

Discovering Non-Linear Boolean Functions by Evolving Walsh Transforms with Genetic Programming

open access: yesAlgorithms, 2023
Stream ciphers usually rely on highly secure Boolean functions to ensure safe communication within unsafe channels. However, discovering secure Boolean functions is a non-trivial optimization problem that has been addressed by many optimization ...
Luigi Rovito   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Adaptive Evolutionary Programming

open access: yesMonthly Weather Review, 2015
Abstract Previous work has shown that evolutionary programming is an effective method for constructing skillful forecast ensembles. Here, two prototype adaptive methods are developed and tested, using minimum temperature forecast data for Chicago, Illinois, to determine whether they are capable of incorporating improvements to forecast ...
openaire   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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