Results 91 to 100 of about 604,094 (289)

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Evolutionary Game Theoretic Analysis of Advanced Persistent Threats Against Cloud Storage

open access: yesIEEE Access, 2017
Advanced Persistent Threats (APTs) represent stealthy, powerful, long-term, and well-funded attacks against cyber systems, such as data centers and cloud storage.
Ahmed A. Alabdel Abass   +3 more
doaj   +1 more source

Reentrant phase transitions and defensive alliances in social dilemmas with informed strategies

open access: yes, 2015
Knowing the strategy of an opponent in a competitive environment conveys obvious evolutionary advantages. But this information is costly, and the benefit of being informed may not necessarily offset the additional cost.
Perc, Matjaz, Szolnoki, Attila
core   +1 more source

Epictetusian rationality and evolutionary stability

open access: yesJournal of Evolutionary Economics
An economic interpretation of Epictetus’s precept of ‘Taking away aversion from all things not in our power’ consists of extending the domain of indifference beyond its boundaries under non-ethical preferences, so as to yield indifference between outcomes differing only on things outside one’s control. This paper examines the evolutionary dynamics of a
openaire   +3 more sources

Evolutionary stability and efficiency [PDF]

open access: yesEconomics Letters, 1993
Abstract ‘One of the advantages of moral philosophy over game theory is that moralists give sensible advice to moral agents while game theory can give stupid advice to game theorists’ — Ian Hacking.
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The evolutionary stability of mixed strategies

open access: yesTrends in Ecology & Evolution, 2000
I thank H.K. Reeve, R.J. Safran, A. Lotem, and members of the Behavior Lunch Bunch for useful discussions, input and commentary. P.W. Sherman provided helpful comments on a preliminary draft. I thank P.H. Crowley for helpful suggestions and for checking the accuracy of this report on his work.
openaire   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Spatio-temporal eco-evolutionary dynamics of prey-predator systems with defended and undefended prey

open access: yesCommunications Physics
The dynamic interplay between evolutionary adaptations and ecological processes has emerged as a key focus for understanding biodiversity and species interactions.
Sourav Roy   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

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