Results 61 to 70 of about 3,044,939 (297)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Designing and engineering evolutionary robust genetic circuits
Journal of Biological Engineering, 2010 Background One problem with engineered genetic circuits in synthetic microbes is their stability over evolutionary time in the absence of selective pressure.
Lieviant Jane A +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Alexandria Engineering Journal, 2020 Based on the stability theory of nonlinear differential equation, this paper analyzes the stability of the evolutionary game supply chain, and obtains the strategies that both sides should adopt in different situations.
Huiqun Yuan +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Evolution of Cooperation in the Prisoner’s Dilemma
Czech Journal of International Relations, 2011 This text offers a review of the literature on the evolution of cooperation in the Prisoner’s Dilemma. The scope of the article is limited to the two-person repeated game and with respect to the emergence of cooperation it is focused upon the mechanism ...
Matúš Halás
doaj
Analysis and classification of fixed points of operators on a simplex
Қарағанды университетінің хабаршысы. Математика сериясыThis paper investigates the dynamical behavior of Lotka–Volterra type operators defined on the four and five dimensional simplexes, focusing on their fixed points and structural representation through directed graphs (tournaments).
D.B. Eshmamatova, M.A. Tadzhieva
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
SystemsSustainable development serves as a key gripper and critical juncture for disaster-stricken regions to achieve the goal of “building back better”, and post-disaster reconstruction (PDR) involves complex system engineering.
Zhiting Song, Jianhua Zhu, Jingwen Bao
doaj +1 more source