Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
QUANTITATIVE GENETICS OF BRYOZOAN PHENOTYPIC EVOLUTION. I. RATE TESTS FOR RANDOM CHANGE VERSUS SELECTION IN DIFFERENTIATION OF LIVING SPECIES [PDF]
Alan H. Cheetham +2 more
openalex +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Ibn Khaldun and Historical Sociology [PDF]
Ibn Khaldun’s Introduction is concerned with the changes of society. Which area of knowledge encompasses his evolutionism doctrine? Analytical history, philosophy of history, static or dynamic sociology, or historical sociology. Which one?
Majid Kafi
doaj
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Reverse Engineering and Cognition Panglossian Memories?
Daniel C. Dennett has dedicated a great part of his work to the conception of an application of reverse engineering and adaptationism in order to explain the evolution of the human mind.
Liliana Chaves Castaño +1 more
doaj
Telocytes and Their Structural Relationships With the Sperm Storage Tube and Surrounding Cell Types in the Utero-Vaginal Junction of the Chicken. [PDF]
Zhu X +7 more
europepmc +1 more source
Secular Evolution Versus Hierarchical Merging: Galaxy Evolution Along the Hubble Sequence, in the Field and Rich Environments [PDF]
Francoise Combes
openalex +1 more source
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini +13 more
wiley +1 more source
Heterologous Dimension of the Other Sociality in the Cognitive Space of Uncertainty. [PDF]
Zhussupova BZ +3 more
europepmc +1 more source

