Results 71 to 80 of about 10,127 (260)
Modeling, Simulation and Application of Bacterial Transduction in Genetic Algorithms [PDF]
, 2009 At present, all methods in Evolutionary Computation are bioinspired in the fundamental principles of neo-Darwinism as well as on a vertical gene transfer. Thus, on a mechanism in which an organism receives genetic material from its ancestor.
Carlos Perales-Gravan +2 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Thinking in Terms of System Hierarchies and Velocites. What makes Development Sustainable? [PDF]
In order to understand the context for sustainable development policies it is necessary to understand how different rates of evolution and velocities of change within social and ecological systems affect interactions between and the co-evolution of those
Jörg Köhn
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Adaptive Probability Theory: Human Biases as an Adaptation [PDF]
, 2005 Humans make mistakes in our decision-making and probability judgments. While the heuristics used for decision-making have been explained as adaptations that are both efficient and fast, the reasons why people deal with probabilities using the reported ...
Martins, André C. R.
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
SERVICE BASED APPROACH FOR ADAPTABILITY OF WORKFLOW MODELS: THE SUBCONTRACTING ARCHITECTURE [PDF]
, 2012 International audienceThe environment of businesses is naturally unstable and dynamic due to increasing market constraints and events. Thus business processes are frequently subject to changes which must be supported by process models and systems that ...
Alimazighi, Zaia +3 more
core +1 more source
Scaling Regimes in the Distribution of Galaxies
, 1998 If we treat the galaxies in published redshift catalogues as point sets, we may determine the generalized dimensions of such sets by standard means, outlined here.
Murante, G. +3 more
core +1 more source
Constraint handling strategies in Genetic Algorithms application to optimal batch plant design [PDF]
, 2008 Optimal batch plant design is a recurrent issue in Process Engineering, which can be formulated as a Mixed Integer Non-Linear Programming(MINLP) optimisation problem involving specific constraints, which can be, typically, the respect of a time horizon ...
A. Ponsich +32 more
core +4 more sources