Results 221 to 230 of about 29,904 (250)

Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

Biochemical Journal, 2009
In Ewing's sarcomas, chromosomal translocations cause the N-terminal domain of the EWS (Ewing's sarcoma protein) to fuse with the DNA-binding domains of the Ets (E26 transformation-specific) family of transcription factors. Here we show that EWS and EWS-Fli1 (Friend leukaemia virus integration 1), the fusion most frequently found in Ewing's sarcomas ...
Klevernic, Iva V., Morton, Simon, Davis, Roger J., Cohen, Philip   +3 more
openaire   +3 more sources

Targeting the EWS–FLI1 transcription factor in Ewing sarcoma

Cancer Chemotherapy and Pharmacology, 2015
Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. This combination was evaluated in Ewing sarcoma patient who was progressing with standard therapies.Trabectedin was
Tancredi, R, Zambelli, A, DaPrada, G A, Fregoni, V, Pavesi, L, Riccardi, A, Burdach, S, Grohar, P J, D'Incalci, M   +8 more
openaire   +4 more sources

Ewing Sarcoma

Abstract: Ewing sarcoma (ES) is the second most common primary musculoskeletal neoplasm in children and adolescents after osteosarcoma with a peak between 10 and 20. Rarely, the tumor develops in newborns or in adults over the age of 30. ES can affect either the appendicular or axial skeleton. Extraosseous ES is less prevalent. Clinical presentation is
Vanhoenacker, Filip M., Van Kerkhove, Filip, Bosmans, Frederik, Brys, Peter   +3 more
openaire   +2 more sources

Ewing's tumor of the mandible

Oral Surgery, Oral Medicine, Oral Pathology, 1993
A primary Ewing's tumor in the mandible is reported, and the diagnostic imaging features of this lesion are discussed. Modalities used included panoramic and plain films, computed tomography, and 99mTc-MDP scintigraphy.
GURBUZER, B, YENICI, O, TUROGLU, HT, OZDAMAR, S, YALCIN, S, SADIKOGLU, Y   +5 more
openaire   +4 more sources

EWS–ETS oncoproteins: The linchpins of Ewing tumors

Gene, 2005
Ewing tumors, which comprise Ewing's sarcoma and peripheral primitive neuroectodermal tumors, are highly aggressive and mostly affect children and adolescents. Their molecular signature is a chromosomal translocation leading to the generation of EWS-ETS (or very rarely FUS-ETS) fusion proteins that are capable of transforming cells.
openaire   +2 more sources

Hypocalcaemia in ewes

Veterinary Record, 1985
J, Kemp, R M, Maff, G D, Wilson
openaire   +2 more sources

Comparison between the reproductive performance of ewe hoggets and mature ewes following a progesterone‐based oestrus synchronization protocol

New Zealand Journal of Agricultural Research, 2013
Paul Kenyon, Pch Morel, Dm West
exaly  

The effect of ewe size and nutritional regimen beginning in early pregnancy on ewe and lamb performance to weaning

New Zealand Journal of Agricultural Research, 2009
Sw Peterson, Hugh Blair, C M C Jenkinson   +2 more
exaly  

Chemical composition and microbiological quality of ewe and goat milk of native Greek breeds

Small Ruminant Research, 2012
M C Katsiari
exaly  

A comparison of the reproductive performance of ewe lambs and mature ewes

Small Ruminant Research, 2013
S T Morris, P C H Morel, D M West
exaly