Results 31 to 40 of about 16,801 (243)

Rijksoverheid [PDF]

open access: yesMAB, 2004
Dit artikel gaat over het bewust en harmonieus hanteren van de mix aan instrumenten bij het uitoefenen van (extern) toezicht. Onderscheid wordt daarbij gemaakt tussen ex ante en ex post instrumenten; gesteld wordt dat de kwaliteit van ex ante ...
A. Molenkamp, M. P. Tummers
doaj   +3 more sources

Vulnerability management practices for sustainable livelihood security in drought-prone Gamo lowlands: An empirical insight from southwest Ethiopia

open access: yesHeliyon, 2022
Vulnerable people do not always absorb the occurring shocks instead they react to disasters employing multiple strategies. This study mainly aims to explore households' vulnerability management practices and their linkages with sustainable livelihood ...
Thomas Toma Tora   +2 more
doaj   +1 more source

Ex ante Randomization in Agency Models [PDF]

open access: yesThe RAND Journal of Economics, 1984
We consider how a principal can use randomized strategies in designing optimal contracts in agency settings. We distinguish between ex post randomization (overfee schedulesfollowing act selection by the agent) and ex ante randomization (overfee schedules before act selection). We show that ex ante randomization may be efficient in both full information
KWON, Young Koan   +2 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

La frontera de distribución en Colombia [PDF]

open access: yesRevista de Economía Institucional, 2011
En este artículo se calcula la frontera de distribución en Colombia con datos de las matrices de oferta y utilización de productos de 2005 a precios corrientes usando un modelo de capital circulante basado en Sraffa, Pasinetti y Muñoz y Riaño.
Mario García M, Carlos A. Garzón R
doaj   +1 more source

Kajian Perkiraan Dampak Rencana Pembangunan Pelabuhan Onshore Bagi Masyarakat di Pesisir Kota Pekalongan

open access: yesJurnal Pembangunan Wilayah dan Kota
Pelabuhan Perikanan Nusantara Pekalongan (PPNP) mengalami penurunan kinerja akibat banjir rob dan penurunan tanah. Pemerintah Kota Pekalongan berupaya mengatasi permasalahan tersebut melalui rencana pembangunan Pelabuhan Onshore untuk meningkatkan sektor
Tia Dianing Insani, Iwan Rudiarto
doaj   +1 more source

Impacts of intellectual property provisions in trade treaties on access to medicine in low and middle income countries: a systematic review

open access: yesGlobalization and Health, 2019
Background We present a systematic review describing ex-ante and ex-post evaluations of the impacts of intellectual property provisions in trade treaties on access to medicine in low and middle income countries.
Md. Deen Islam   +5 more
doaj   +1 more source

Influence of Project Governance on Opportunistic Behavior: Taking a Dynamic Perspective

open access: yesBuildings, 2022
The importance of project governance in curbing opportunistic behavior (OB) has been clearly established in the project literature. Although contract governance and trust are considered critical factors that explain project governance, there is a lack of
Wenjing Han, Yilin Yin
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

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