Results 201 to 210 of about 17,179 (263)

Genomics‐informed management of ex situ populations

Conservation Biology, EarlyView.
Abstract The European Association of Zoos and Aquariums (EAZA) manages insurance populations for hundreds of species through its EAZA ex situ programs (EEPs). EEPs help safeguard against extinction in the wild and provide source populations for genetic rescue programs.
Cock van Oosterhout, Philippe Helsen, Elmar Fienieg, Claudia Fontsere, Linett Rasmussen, Mirte Bosse, Zjef Pereboom, Christina Hvilsom, Hernán E. Morales   +8 more
wiley   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Successful phased‐release reintegration of captive‐origin cheetah for metapopulation supplementation

Conservation Science and Practice, EarlyView.
Conservation programs increasingly require consideration of rehabilitated individuals for translocations to reduce pressure on highly threatened wild populations. This case‐study evaluates the short‐term translocation success of captive‐origin cheetah (Acinonyx jubatus) after phased‐release reintegration into the wild in South Africa.
Allison A. Muller, Willem Briers‐Louw, Marna Smit, Nynke Wemer, Olivia Sievert, Alison J. Leslie, Vincent N. Naude   +6 more
wiley   +1 more source

Focusing solely on genetics may harm the conservation of critically endangered species: A comment to Skorupski et al. (2025)

Conservation Science and Practice, EarlyView.
Madis Põdra, Grete Nummert‐Meister, Kristel Nemvalts, María Díez‐León, Kairi Kiik, Martin Silts, Asunción Gómez, Lauren A. Harrington, Klaus‐Peter Koepfli, Tiit Maran   +9 more
wiley   +1 more source

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CONSERVATION CHALLENGES AND IN SITU AND EX SITU APPROACHES TO REPTILE CONSERVATION

2022
Not ...
Crottini, A., Gardner, C. J., Pedrono, M., Jenkins, R. K. B., Behra, O., Ramy, A., Raxworthy, C. J.   +6 more
openaire   +4 more sources

Ex Situ Conservation

2017
This chapter looks into ex situ conservation. It acknowledges that in situ conservation techniques might be needed if a successful ex situ conservation programme, which is termed reintroduction, is achieved. The chapter explores the subdivisions of ex situ conservation: intensive or general captive breeding programmes and gene banks.
Anne E. Goodenough, Adam G. Hart
openaire   +1 more source

Ex Situ Conservation

2019
This chapter focuses on ex situ (off-site) conservation, which is the protection and management of biodiversity in artificial, human-built environments. Indeed, ex situ conservation allows wild-caught individuals to be maintained under close human supervision in facilities like zoos, aquariums, botanical gardens, or arboretums.
Bradley J. Cardinale, Richard B. Primack, James D. Murdoch   +2 more
openaire   +1 more source

The science and economics of ex situ plant conservation

Trends in Plant Science, 2009
Ex situ seed storage underpins global agriculture and food supplies and enables the conservation of thousands of wild species of plants within national and international facilities. As an insurance policy against extinction, ex situ seed conservation is estimated to cost as little as 1% of in situ conservation.
De-Zhu, Li, Hugh W, Pritchard
openaire   +2 more sources