Results 51 to 60 of about 3,495 (168)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Dignity's Dilemma: Categorical Objections to Autonomous Weapons and Their Pacifist Entailments

Journal of Applied Philosophy, EarlyView.
ABSTRACT Dignity objections to autonomous weapon systems are prominent in contemporary military ethics, yet their theoretical foundations remain underexamined. This article reconstructs those foundations, showing what categorical dignity objections require to function as absolute prohibitions.
Timothy Dubber
wiley   +1 more source

Foreign body ingestions in children and adolescents: A position paper of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) endoscopy special interest group

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Foreign body (FB) ingestion is a relatively frequent occurrence in the pediatric population with multiple potential sequelae. Appropriate intervention may range from urgent endoscopic retrieval to watchful waiting, with multiple variables influencing the decision.
Oren Ledder, Raoul Furlano, Alexandra Papadopoulou, Dominique Schluckebier, Andreia Nita, Christos Tzivinikos, Salvatore Oliva, Simona Faraci, Luigi Dall'oglio, Marco Deganello Saccomani, Priya Narula, Iva Hojsak, Jorge Amil Dias, Vasiliki Spyropoulou, Lorenzo Norsa, Gokhan Baysoy, Claudio Romano, Matjaž Homan, Mike Thomson   +18 more
wiley   +1 more source

The Use of Blue Light as an Antimicrobial Treatment Against Staphylococcus aureus: A Systematic Review

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Background Staphylococcus aureus (S. aureus) is a major cause of skin, wound, and device‐related infections. Blue light (405–470 nm), shows promise for treating this organism. However, the translatability, dosing parameters, safety, and effectiveness remain unclear, and no systematic review currently exists.
Alexander Idrogo‐Lam, Kofi Owusu‐Ansah, Eric Cotter, Lisa Cotter   +3 more
wiley   +1 more source

Unveiling power, or why social science's task is explanation

The British Journal of Sociology, EarlyView., 2023
Abstract This short essay contends that sociology should devote attention to causal explanation in order to expose lies. It argues that lies about causes are common in society and social science is in a unique privileged position to offer social knowledge that can dispel such lies. Offering causal explanations is a vital task of this project.
Julian Go
wiley   +1 more source

Homogenous Cell Transplantation Trials in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The transplantation of homogenous cells has emerged as an investigational strategy for Parkinson's disease (PD), offering an alternative to symptomatic treatment. Objective We performed a systematic review and meta‐analysis to assess its clinical efficacy and safety.
Nolan Reinisch, Athena Mancini, Adham Elsherbini, Jason Yuen, Andres Lozano   +4 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Insights into the thermal ecology, physiology, and behavior of a threatened ectothermic specialist from a warming and drying ecoregion. [PDF]

Biol Open
Blais BR, Mazzamuto MV, Koprowski JL.
europepmc   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

Naval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

A renewed perspective on TCA intermediate cis-aconitate: mechanisms and therapeutic options against influenza virus. [PDF]

EMBO Mol Med
Claus C, Kovacevic I.
europepmc   +1 more source