Results 51 to 60 of about 3,432 (168)

Homogenous Cell Transplantation Trials in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The transplantation of homogenous cells has emerged as an investigational strategy for Parkinson's disease (PD), offering an alternative to symptomatic treatment. Objective We performed a systematic review and meta‐analysis to assess its clinical efficacy and safety.
Nolan Reinisch, Athena Mancini, Adham Elsherbini, Jason Yuen, Andres Lozano   +4 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

Naval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

Accelerating the prioritisation of plant species with underexplored medicinal potential: The pm4mp (Phylogenetic Methods for Medicinal Plants) R package

PLANTS, PEOPLE, PLANET, EarlyView.
Medicinal plants used in ethnobotanical traditions to treat or prevent diseases have gained renewed interest for their largely untapped potential in drug discovery. In this study, we developed and tested novel methods to prioritise plant species based on their unexplored medicinal potential. By enabling researchers to target the most promising species,
Giovanni Zecca, Elisa Toini, Massimo Labra, Fabrizio Grassi   +3 more
wiley   +1 more source

High‐Flow Nasal Oxygen in Early Home Pulmonary Rehabilitation for Exertional Hypoxaemia: A Pilot Randomised Feasibility Trial

Respirology, EarlyView.
Summary This pilot randomised feasibility trial evaluated the feasibility and acceptability of early, intensive home‐based pulmonary rehabilitation (PR) and high‐flow nasal oxygen (HFO) during exercise in patients with exertional hypoxaemia post‐hospitalisation. Early home‐based PR was feasible and safe.
Yingjuan Mok, Jing Wen Foong, Hang Siang Wong, Edwin Chan Shih‐Yen, Norasyikin Hassan, Piyanee Klainin‐Yobas, Li Ching Soh, Amanda Soh, Shi Hua Tan, Xuan Han Koh, Poh Choo Tan, Keith Keat Huat Wong   +11 more
wiley   +1 more source

Science for All? A Systematic Literature Review on Effective Teaching Approaches in Inclusive and Separate Settings

Science Education, EarlyView.
ABSTRACT This systematic literature review examines intervention studies focused on teaching science to a diverse range of learners. It adopts a broad definition of inclusion and makes use of the PRISMA statement. The review aims to provide an overview of evidence‐based teaching approaches in the current literature, identify the science skills targeted,
Silvia Fränkel, Nadine Großmann, Melanie Basten   +2 more
wiley   +1 more source

Climate Vulnerability and Renewable Energy Consumption: The Moderating Role of Financial Development

Sustainable Development, EarlyView.
ABSTRACT This study investigates the nexus between climate vulnerability (CVUL) and renewable energy consumption (RECO) and tests the moderating effect of financial development (FD) on this relationship. The analysis is, particularly, relevant for the 162 panel countries observed between 1995 and 2022, which face diverse climate risks and exhibit ...
Sorin Gabriel Anton
wiley   +1 more source

Insights into the thermal ecology, physiology, and behavior of a threatened ectothermic specialist from a warming and drying ecoregion. [PDF]

Biol Open
Blais BR, Mazzamuto MV, Koprowski JL.
europepmc   +1 more source

The Strategic Logic of Biodiversity: Why Firms Invest in Nature‐Based Initiatives

Sustainable Development, EarlyView.
ABSTRACT Biodiversity loss poses profound strategic and operational challenges for firms, yet management research offers limited evidence on which organisational mechanisms effectively reduce corporate biodiversity impacts. This study introduces the Biodiversity Strategy Configuration Framework (BSCF) to enhance the understanding of firm‐level ...
Post Raj Pokharel
wiley   +1 more source

A renewed perspective on TCA intermediate cis-aconitate: mechanisms and therapeutic options against influenza virus. [PDF]

EMBO Mol Med
Claus C, Kovacevic I.
europepmc   +1 more source