Results 111 to 120 of about 7,457,259 (243)
Molecular Glue Degraders in Early Development for Cancer Therapy
Medicinal Research Reviews, EarlyView.ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir +4 more
wiley +1 more source
Unveiling power, or why social science's task is explanation
The British Journal of Sociology, EarlyView., 2023 Abstract This short essay contends that sociology should devote attention to causal explanation in order to expose lies. It argues that lies about causes are common in society and social science is in a unique privileged position to offer social knowledge that can dispel such lies. Offering causal explanations is a vital task of this project.
Julian Go
wiley +1 more source
Unequal Uncertainties and Uncertain Inequalities: An Axiomatic Approach [PDF]
In this paper, we provide an axiomatic characterization of social welfare functions for uncertain incomes. Our most general result is that a small number of reasonable assumptions regarding welfare orderings under uncertainty rule out pure ex ante as ...
Thibault Gajdos, Eric Maurin
core
Neuroprotection, EarlyView.This systematic review and meta‐analysis assessed the cytoprotective effects of neuromodulation in preclinical models of ischemic stroke. Pooled analyses showed that neuromodulation significantly reduced infarct volume and improved neurological outcomes.
Igor Caitano Salles +7 more
wiley +1 more source
Evaluating the conditions for robust mechanism design [PDF]
We assess the strength of the different conditions identified in the literature of robust mechanism design. We focus on three conditions: ex post incentive compatibility, robust monotonicity, and robust measurability.
Roberto Serrano, Takashi Kunimoto
core
Mobilizing Presence across Borders: Devotion to Papua New Guinea's Blessed Peter To Rot in Australia
Oceania, EarlyView.ABSTRACT This article engages with the conjunctures between migration and religion by focusing on the celebration of Papua New Guinea's ‘National Patron Saint’, the Blessed Peter To Rot, in the Australian diaspora. Both in Sydney and Brisbane, Catholic Papua New Guinea (PNG) migrants have been ‘relocating’ PNG shrines, regalia, relics and ritual ...
Anna‐Karina Hermkens
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Medicinal plants used in ethnobotanical traditions to treat or prevent diseases have gained renewed interest for their largely untapped potential in drug discovery. In this study, we developed and tested novel methods to prioritise plant species based on their unexplored medicinal potential. By enabling researchers to target the most promising species,
Giovanni Zecca +3 more
wiley +1 more source
How do ex ante simulations compare with ex post evaluations ? evidence from the impact of conditional cash transfer programs [PDF]
This paper compares the ex ante simulation of the impacts of conditional cash transfer programs against the ex post estimates of impacts obtained from experimental evaluations.
Narayan, Ambar +2 more
core
Leaving orthopaedic surgical training: the LOST surgeons - a qualitative study exploring why UK trauma and orthopaedic registrars discontinue surgical training. [PDF]
BMJ OpenMaggs J +7 more
europepmc +1 more source
Respirology, EarlyView.Summary This pilot randomised feasibility trial evaluated the feasibility and acceptability of early, intensive home‐based pulmonary rehabilitation (PR) and high‐flow nasal oxygen (HFO) during exercise in patients with exertional hypoxaemia post‐hospitalisation. Early home‐based PR was feasible and safe.
Yingjuan Mok +11 more
wiley +1 more source