Results 111 to 120 of about 4,331,512 (295)

POINT EXPLOSION WITHIN A CAVITY WITH A POWER-LAW DENSITY DISTRIBUTION

Odessa Astronomical Publications, 2017
An exact analytic solution based on the Kompaneets approximation is found for a shock wave expansion from a point explosion within a preexisting interstellar gas cavity with a power-law gas density distribution.
V. V. Martiushov, S. A. Silich
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An asymptotically exact, pointwise, a posteriori error estimator for linear, elliptic, one dimensional problems with possible singularities in the solution

, 1994
When the finite element solution of a variational problem possesses certain super convergence properties, it is possible very inexpensively to obtain a correction term providing an additional order of approximation of the solution.
Jens Hugger, Asymptotically Exact Pointwise   +1 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Representation of the Exact Solution of Generalized Lane-Emden Equations Using a New Analytical Method

Abstract and Applied Analysis, 2013
A new analytic method is applied to singular initial-value Lane-Emden-type problems, and the effectiveness and performance of the method is studied. The proposed method obtains a Taylor expansion of the solution, and when the solution is polynomial, our ...
Omar Abu Arqub, Ahmad El-Ajou, A. Sami Bataineh, I. Hashim   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analytic numerical solution of coupled semi-infinite diffusion problems [PDF]

, 1995
In this paper, we consider coupled semi-infinite diffusion problems of the form ut(x, t)− A2 uxx(x,t) = 0, x > 0, t > 0, subject to u(0,t)=B and u(x,0)=0, where A is a matrix in Cr×r, and u(x,t), and B are vectors in Cr. Using the Fourier sine transform,
Jódar, L., Goberna, D.
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source