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Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Optimizing exact genetic linkage computations

Proceedings of the seventh annual international conference on Research in computational molecular biology, 2003
Genetic linkage analysis is a challenging application which requires Bayesian networks consisting of thousands of vertices. Consequently, computing the probability of data, which is needed for learning linkage parameters, using exact computation procedures calls for an extremely efficient implementation that carefully optimizes the order of ...
Ma'ayan, Fishelson, Dan, Geiger
openaire   +2 more sources

EXACT GEOMETRIC COMPUTATION USING CASCADING

International Journal of Computational Geometry & Applications, 2001
In this paper we talk about a new efficient numerical approach to deal with inaccuracy when implementing geometric algorithms. Using various floating-point filters together with arbitrary precision packages, we develop an easy-to-use expression compiler called EXPCOMP. EXPCOMP supports all common operations [Formula: see text].
Burnikel, C., Funke, S., Seel, M.
openaire   +2 more sources

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