Results 11 to 20 of about 870 (53)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Signature of cooperativity in the stochastic fluctuations of small systems with application to the bacterial flagellar motor. [PDF]

Sci Rep
Franco-Oñate MJ, Parmeggiani A, Dorignac J, Geniet F, Walter JC, Pedaci F, Nord AL, Palmeri J, Walliser NO.   +8 more
europepmc   +1 more source

Sackin indices for labeled and unlabeled classes of galled trees. [PDF]

J Math Biol
Fuchs M, Gittenberger B.
europepmc   +1 more source

Counting Spinal Phylogenetic Networks. [PDF]

Bull Math Biol
Francis A, Hendriksen M.
europepmc   +1 more source

Crossover operators for molecular graphs with an application to virtual drug screening. [PDF]

J Cheminform
Domschke N, Schmidt BJ, Gatter T, Golnik R, Eisenhuth P, Liessmann F, Meiler J, Stadler PF.   +7 more
europepmc   +1 more source

PIPI-C: A Combinatorial Optimization Framework for Identifying Post-translational Modification Hot-spots in Mass Spectrometry Data. [PDF]

Mol Cell Proteomics
Lai S, Dai S, Zhao P, Zhou C, Li N, Yu W.   +5 more
europepmc   +1 more source

Application and Prospects of Large Language Models in Small-Molecule Drug Discovery. [PDF]

Anal Chem
Ma J, Liu J, Xu D, Song X, Zhang Z.
europepmc   +1 more source

Optimization of emergency logistics for urban flooding with consideration of rainfall effects. [PDF]

Sci Rep
Zhang P, Zhang C, Zhang P, Yan X, Yang H.   +4 more
europepmc   +1 more source