Results 11 to 20 of about 6,630 (193)

Exact enumeration of cherries and pitchforks in ranked trees under the coalescent model. [PDF]

Mathematical Biosciences, 2011
We consider exact enumerations and probabilistic properties of ranked trees when generated under the random coalescent process. Using a new approach, based on generating functions, we derive several statistics such as the exact probability of finding k ...
F. Disanto, T. Wiehe
semanticscholar   +1 more source

Exact Method for Solving Single Machine Scheduling Problem Under Fuzzy Due Date to Minimize Multi-Objective Functions

, 2021
In this paper, the branch and bound technique used to solve a single machine scheduling problem, which is the problem of scheduling n-job on a single machine of multi-objective function with triangle fuzzy due date numbers which are formulated as 1\D˜j ...
Hanan A. Cheachan, M. Kadhim
semanticscholar   +1 more source

Analytic Combinatorics of Lattice Paths with Forbidden Patterns, the Vectorial Kernel Method, and Generating Functions for Pushdown Automata

Algorithmica, 2019
In this article we develop a vectorial kernel method—a powerful method which solves in a unified framework all the problems related to the enumeration of words generated by a pushdown automaton. We apply it for the enumeration of lattice paths that avoid
Andrei Asinowski, A. Bacher, C. Banderier, Bernhard Gittenberger   +3 more
semanticscholar   +1 more source

Exact enumeration study of free energies of interacting polygons and walks in two dimensions [PDF]

, 1998
We present analyses of substantially extended series for both interacting self-avoiding walks (ISAW) and polygons (ISAP) on the square lattice. We argue that these provide good evidence that the free energies of both linear and ring polymers are equal ...
D. Bennett-Wood, I. Enting, D. S. Gaunt, A. Guttmann, J. Leask, A. Owczarek, S. Whittington   +6 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source