Results 11 to 20 of about 1,020 (183)
Combinatorial properties of phylogenetic networks [PDF]
, 2020 This thesis is concerned with combinatorial properties of some subclasses of rooted and unrooted phylogenetic networks. We consider several phylogenetic networks and provide enumeration formulas (exact and asymptotic) for them with a given number of ...
Mansouri, Marefatollah
core +1 more source
Graph enumeration and random graphs [PDF]
, 2017 In this thesis we use analytic combinatorics to deal with two related problems: graph enumeration and random graphs from constrained classes of graphs. We are interested in drawing a general picture of some graph families by determining, first, how many ...
Ramos Garrido, Lander
core +1 more source
Random combinatorial structures and randomized search heuristics [PDF]
, 2010 This thesis is concerned with the probabilistic analysis of random combinatorial structures and the runtime analysis of randomized search heuristics. On the subject of random structures, we investigate two classes of combinatorial objects.
Johannsen, Daniel, Johannsen, D.
core +1 more source
Combinatorics of lattice paths and tree-like structures [PDF]
, 2016 This thesis is concerned with the enumerative and asymptotic analysis of directed lattice paths and tree-like structures. We introduce several new models and analyze some of their characterizing parameters, such as the number of returns to zero, or their
Wallner, Michael; orcid:
core +1 more source
Study of combinatorial statistics and their impact on evolutionary optimization
, 2021 This thesis studies combinatorial objects, with both an algorithmic and a combinatorial point of view. In the combinatorial part, we take care first, the enumeration of Catalan words avoiding pairs of patterns of length three, presenting the proofs of
Khalil, Carine
core +1 more source
New results on the enumeration of non-intersecting random walks
, 1988 Many attempts have been made to obtain approximations and closed forms for the generating function enumerating non-intersecting (self-avoiding) walks on a periodic lattice.
Temperley, H.N.V.
core +1 more source
Statistics for transcription factor binding sites
, 2008 Transcription factors (TFs) play a key role in gene regulation. They interact with specific binding sites or motifs on the DNA sequence and regulate expression of genes downstream of these binding sites.
Pape, Utz J., Pape, U.
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source