Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
A simple spiking retina model for exact video stimulus representation
BMC Neuroscience, 2008 Pnevmatikakis Eftychios A, Lazar Aurel A
doaj +1 more source
Symptom predominance, treatment delay, and four-year remission outcomes in first-episode schizophrenia: A single-center cohort from Turkiye. [PDF]
Dusunen AdamAkbas I, Guclu O.
europepmc +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Geometry-Mechanics Compatibility Enables Interpretable Inverse Design of Non-Rigid Origami. [PDF]
Research (Wash D C)Sun Y +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
The refinement of repeated exact time-to-event modeling: methodological refinements and implementation in NONMEM<sup>®</sup> -part I. [PDF]
Front PharmacolSeo J, Lim HS.
europepmc +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Association between the alkaline phosphatase-to-albumin ratio and recorded early all-cause mortality within 90 days of admission in patients with heart failure: a retrospective cohort study in a Chinese population. [PDF]
Front Cardiovasc MedYuan Z +8 more
europepmc +1 more source