Results 41 to 50 of about 1,121 (263)
Cosmological solutions of a nonlocal square root gravity
Physics Letters B, 2019 In this paper we consider modification of general relativity extending R−2Λ by nonlocal term of the form R−2ΛF(□)R−2Λ, where F(□) is an analytic function of the d'Alembert operator □.
I. Dimitrijevic +4 more
doaj +1 more source
European Physical Journal C: Particles and Fields, 2021 We develop an approach to the theory of relativistic geometric flows and emergent gravity defined by entropy functionals and related statistical thermodynamics models. Nonholonomic deformations of G.
Sergiu I. Vacaru +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Causal Gödel-type metrics in non-local gravity theories
European Physical Journal C: Particles and Fields, 2021 It is well known that non-local theories of gravity have been a flourish arena of studies for many reasons, for instance, the UV incompleteness of General Relativity (GR). In this paper we check the consistency of ST-homogeneous Gödel-type metrics within
J. R. Nascimento +2 more
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Critical Phenomena in Gravitational Collapse
Living Reviews in Relativity, 2007 As first discovered by Choptuik, the black hole threshold in the space of initial data for general relativity shows both surprising structure and surprising simplicity.
Martín-García José M. +1 more
doaj
Inhomogeneous spacetimes in Weyl integrable geometry with matter source
European Physical Journal C: Particles and Fields, 2020 We investigate the existence of inhomogeneous exact solutions in Weyl Integrable theory with a matter source. In particular, we consider the existence of a dust fluid source while for the underlying geometry we assume a line element which belongs to the ...
Andronikos Paliathanasis +2 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source