Results 71 to 80 of about 1,118 (293)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

The Non-Autonomous Chiral Model and the Ernst Equation of General Relativity in the Bidifferential Calculus Framework

Symmetry, Integrability and Geometry: Methods and Applications, 2011
The non-autonomous chiral model equation for an m×m matrix function on a two-dimensional space appears in particular in general relativity, where for m=2 a certain reduction of it determines stationary, axially symmetric solutions of Einstein's vacuum ...
Aristophanes Dimakis, Nils Kanning, Folkert Müller-Hoissen   +2 more
doaj   +1 more source

Inflationary f (R) Cosmologies

Universe, 2017
This paper discusses a simple procedure to reconstruct f ( R ) -gravity models from exact cosmological solutions of the Einstein field equations with a non-interacting classical scalar field-and-radiation background.
Heba Sami, Joseph Ntahompagaze, Amare Abebe   +2 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Critical Phenomena in Gravitational Collapse

Living Reviews in Relativity, 1999
As first discovered by Choptuik, the black hole threshold in the space of initial data for general relativity shows both surprising structure and surprising simplicity.
Gundlach Carsten
doaj  

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Renyi Type Holographic Dark Energy

Journal of New Theory
Dark energy is one of the prominent mysteries of the universe that still awaits a solution. One of the plausible ways to collect data about any formation or understand its information capacity is to investigate the entropy of that formation.
Arzu Aktaş, İhsan Yılmaz
doaj   +1 more source

Exploring the solitary wave solutions of Einstein's vacuum field equation in the context of ambitious experiments and space missions

Alexandria Engineering Journal, 2023
In the present work, Einstein's vacuum field equation is investigated analytically to explore the solitary wave solutions. This equation arises in mathematical physics, having meaningful applications in the general theory of relativity.
Mustafa Inc, Muhammad S. Iqbal, Muhammad Z. Baber, Muhammad Qasim, Zafar Iqbal, Muhammad Akhtar Tarar, Ali Hasan Ali   +6 more
doaj  

Kerr-Schild double field theory and classical double copy

Journal of High Energy Physics, 2018
The Kerr-Schild (KS) formalism is a powerful tool for constructing exact solutions in general relativity. In this paper, we present a generalization of the conventional KS formalism to double field theory (DFT) and supergravities.
Kanghoon Lee
doaj   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source