Results 81 to 90 of about 77,425 (318)

Energy of spherically symmetric spacetimes on regularizing teleparallelism

, 2010
We calculate the total energy of an exact spherically symmetric solutions, i.e., Schwarzschild and Reissner Nordstr$\ddot{o}$m, using the gravitational energy-momentum 3-form within the tetrad formulation of general relativity.
Nashed, G. G. L.
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Bianchi I solutions of effective quadratic gravity

, 2012
It is believed that soon after the Planck time, Einstein's general relativity theory should be corrected to an effective quadratic theory. Numerical solutions for the anisotropic generalization of the Friedmann "flat" model $E^3$ for this effective ...
de Deus, Juliano A., Müller, Daniel
core   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Semiclassical Effects and the Onset of Inflation

, 1992
We present a class of exact solutions to the constraint equations of General Relativity coupled to a Klein - Gordon field, these solutions being isotropic but not homogeneous.
A. Guth, A. Linde, B. Berger, B. L. Hu, B. L. Hu, B. L. Hu, B. L. Hu, B. L. Hu, C. Misner, D. Goldwirth, D. Goldwirth, D. Goldwirth, D. Goldwirth, D. Salopek, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Calzetta, E. Kolb, E. Malec, Esteban Calzetta, G. G. Ross, G. Smoot, H. Feldman, H. Feldman, H. Kandrup, H. Kandrup, H. Kurki-Suonio, J. Bardeen, J. Frieman, J. Hartle, J. P. Paz, L. Landau, L. Parker, L. Parker, L. Parker, L. Parker, L. Parker, L. Parker, Maria Sakellariadou, P. Bizon, P. Bizon, S. Coleman, S. Coleman, S. Hawking, S. Hawking, S. Weinberg, T. Piran, T. Piran, U. Brauer, W. Unruh, X. Lin, X. Lin, Ya. B. Zel'dovich, Ya. B. Zel'dovich   +60 more
core   +2 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Multipole structure of compact objects

Physical Sciences and Technology, 2017
We analyze the applications of general relativity in relativistic astrophysics in order to solve the problem of describing the geometric and physical properties of the interior and exterior gravitational and electromagnetic fields of compact objects. We
H. Quevedo
doaj  

Renyi Type Holographic Dark Energy

Journal of New Theory
Dark energy is one of the prominent mysteries of the universe that still awaits a solution. One of the plausible ways to collect data about any formation or understand its information capacity is to investigate the entropy of that formation.
Arzu Aktaş, İhsan Yılmaz
doaj   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source