Results 101 to 110 of about 39,746 (259)

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Suggesting a structural model of test anxiety based on early maladaptive schemas with mediating fear of negative evaluation students in Tehran [PDF]

مجله علوم روانشناختی
Background: Exam anxiety is a prevalent psychological and educational challenge among students, significantly impacting their academic performance, mood, and social behaviors. Gaining a deeper understanding of the psychological processes involved in exam
Kourosh Jabari, Bahman Kord, Arezoo Shomali Oskoei   +2 more
doaj  

Immersive Virtual Reality and AI (Generative Pretrained Transformer) to Enhance Student Preparedness for Objective Structured Clinical Examinations: Mixed Methods Study

JMIR Serious Games
BackgroundImmersive virtual reality (VR) and artificial intelligence have been used to determine whether a simulated clinical exam setting can reduce anxiety in first-year occupational therapy students preparing for objective ...
Shaniff Esmail, Brendan Concannon
doaj   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Effective Factors on Successful Comprehensive Exam in Midwifery Students

آموزش پزشکی, 2015
BACKGROUND AND OBJECTIVE: A comprehensive exam that can test midwifery students to evaluate their professional ability is the important. Therefore, this study was conducted to determine the factors influencing the outcome of comprehensive exam on this ...
Mahboubeh Faramarzi, Afsaneh Bakhtiari, Hajar Pasha, Moulood Agajani Delavar, Hajar Salmalian, Fatemeh Nasiri Amiri, Maryam Nikpour, Farideh Mohsenzadeh ladari   +7 more
doaj  

Prevalence and factors causing test anxiety among medical students

Middle East Current Psychiatry
Background Test anxiety (TA) is described as a set of psychological and behavioral responses that occur when a person is concerned about the possibility of unfavorable results or failing on an exam.
Atheer G. Almutairi, Nuran Mazen Baabbad, Almaha Abdullah Alhumaidan, Aljawharah Mohammed Alshahrani, Alanoud Ibrahim Alabdulkarim, Naif Alsughier   +5 more
doaj   +1 more source

Self-Efficacy and Anxiety in Facing School Exams

Psikoborneo: Jurnal Ilmiah Psikologi
Researchers found a problem faced by junior high school students, namely feeling unable to face computer-based exams, which can trigger feelings of anxiety. This quantitative correlational research aims to determine the relationship between self-efficacy and anxiety in junior high students when facing school exams.
Nur Aini, Nengsih Sri Wahyuni, Fuad Ardiansyah   +2 more
openaire   +1 more source