Results 51 to 60 of about 689,888 (317)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

ARCHIVAL INSTITUTIONS AND COPYRIGHT IN KOREA - DOI: 10.12818/P.0304-2340.2023v83p219

Revista da Faculdade de Direito da Universidade Federal de Minas Gerais
Archiving copyrighted materials is often mandated to preserve them for years to come, and especially when handling digital materials created in formats, or housed on media, that are likely to become obsolete.
Gyooho Lee
doaj   +1 more source

Mobile Application Architecture Restructuring with Microservice Approach

JITeCS (Journal of Information Technology and Computer Science), 2021
Microservice is an architecture that can solve many problems in a monolithic architecture. One of the problems is the ability to handle many concurrent users.
Ardiono Roma Nugraha, Aini Suri Talita
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

A critical analysis of the X.400 model of message handling systems [PDF]

, 1988
The CCITT X.400 model of store and forward Message Handling Systems (MHS) serves as a common basis for the definition of electronic mail services and protocols both within CCITT and ISO.
Dorregeest, Evert, Sinderen, Marten van
core   +3 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Intentionally-underestimated value function at terminal state for temporal-difference learning with mis-designed reward

Results in Control and Optimization
Robot control using reinforcement learning has become popular, but its learning process often terminates midway through an episode for safety and time-saving reasons.
Taisuke Kobayashi
doaj   +1 more source

Automated Code Generation For Safety-Related Applications: A Case Study

Computer Science, 2007
This paper addresses issues relating to the suitability of using automated code generation(ACG) technologies for the development of real-time, safety-critical systems.
David P. Gluch, Andrew J. Kornecki
doaj   +1 more source

An evaluation of software fault tolerance techniques in real-time safety-critical applications [PDF]

, 1982
The usefulness of three software fault tolerance techniques -- n-version programming, recovery blocks, and exception handling is examined within the context of real-time safety-critical environments.
Leveson, Nancy G., Yemini, Shaula
core   +1 more source