Results 61 to 70 of about 47,744 (298)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
UUM Journal of Legal StudiesThe COVID-19 pandemic has raised consciousness across the globe of how constitutions respond to crises. This article examines the issue of the Palestinian President declaring a state of emergency in Palestine on March 5, 2020, under Presidential Decree ...
Ahmed Mohammad Hamad +2 more
doaj +1 more source
رقابة القضاء الإداري على تقييد الحريات العامة في الظروف الاستثنائية : دراسة مقارنة. [PDF]
مجلة البحوث القانونية و الاقتصاديةقد لا تصلح السلطات التي تتمتع بها هيئات الضبط الإداري في الظروف العادية لمواجهة الظروف الاستثنائية الخطيرة، التي تهدد الأمن والنظام العام، وتعطل سير المرافق العامة بانتظام واضطراد, مثل تهديد أمن الدولة من خطر حرب خارجية أو وجود اضطرابات داخلية مثل ...
محمد راشد الظنحاني
doaj +1 more source
Should Exceptional Circumstances be declared for anchovy?
, 2021 The survey estimates of anchovy November biomass have been appreciably outside the range that was projected during OMP‐18 simulation testing. In addition, the updated assessment indicates anchovy is less productive than that assumed by the base case Operating Model used during OMP‐ 8 simulation testing.
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
The use of medicines in exceptional circumstances in Spain: adding perspective to early access [PDF]
, 2019 The use of medicines in exceptional circumstances refers to the use of non-authorized medicines or those used outside the authorized conditions, and comprises three different situations: (1) the use of medication in research or for compassionate use; (2)
Lozano Ortiz, Roberto +1 more
core +1 more source
Frontiers in Pharmacology, 2019 BackgroundReimbursement policies influence access of patients to orphan drugs in the European countries.ObjectivesTo provide a comprehensive description of orphan drug reimbursement policies and to assess reimbursement decision-making process in the EU ...
Krzysztof Piotr Malinowski +18 more
doaj +1 more source