Results 61 to 70 of about 145,770 (267)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Spatial Engineering Direct Cooperativity between Binding Sites for Uranium Sequestration

Advanced Science, 2021
Preorganization is a basic design principle used by nature that allows for synergistic pathways to be expressed. Herein, a full account of the conceptual and experimental development from randomly distributed functionalities to a convergent arrangement ...
Qi Sun, Yanpei Song, Briana Aguila, Aleksandr S. Ivanov, Vyacheslav S. Bryantsev, Shengqian Ma   +5 more
doaj   +1 more source

Quaternionic representations of exceptional Lie groups [PDF]

Pacific Journal of Mathematics, 2003
The simply connected complex exceptional Lie groups \(F_4(\mathbf C),\, E_6(\mathbf C),\, E_7(\mathbf C),\, E_8(\mathbf C)\) contain, respectively, the connected quaternionic real forms \(F_{4,4},\, E_{6,4},\, E_{7,4},\, E_{8,4}\) with real root systems of type \(F_4\). \textit{B. H. Gross} and \textit{N. R. Wallach} [J. Reine Angew. Math. 481, 73--123
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Homotopy groups of compact exceptional Lie groups

Proceedings of the Japan Academy, Series A, Mathematical Sciences, 1999
Let \(G\) be a compact, connected, and simply connected simple exceptional Lie group. In this note the authors calculate \(\pi_i(G:3)\), the \(3\)-primary component of \(\pi_i(G)\). The methods used are the standard methods based on killing homotopy groups and homotopy exact sequences of suitable fibrations.
Kachi, Hideyuki, Mimura, Mamoru
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Exceptional groups of Lie type as Galois groups.

Journal für die reine und angewandte Mathematik (Crelles Journal), 1988
Der Autor zeigt die Realisierbarkeit der folgenden einfachen Ausnahmegruppen vom Lie-Typ als Galoisgruppen über der maximalen abelschen Erweiterung \({\mathbb{Q}}^ a\) von \({\mathbb{Q}}:\) \((1)\quad^ 2G_ 2(3^{2n+1});\) \((2)\quad G_ 2(q);\) \((3)\quad^ 3D_ 4(q);\) \((4)\quad F_ 4(q),q\equiv 1\quad mod 2;\) \((5)\quad E_ 6(q),\) \(q\equiv -1\quad mod ...
openaire   +2 more sources