Results 131 to 140 of about 149,354 (217)

Construction and validation of a multimodal MRI-based deep learning model for early differential diagnosis of prostate cancer in the PSA gray zone: a retrospective cohort study. [PDF]

Front Oncol
Xu Z, Ren D, Wang G, Liu H, Zhou Y, Zhu X.   +5 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

WDR12 and HIVEP3 are contributors to cognitive preservation in Amish SuperAgers. [PDF]

Alzheimers Dement
Dorfsman D, Prough MB, Gulyayev A, Caywood LJ, Clouse JE, Herington SD, Slifer SH, Adams LD, Laux RA, Song YE, Lynn A, Fuzzell SL, Hochstetler SD, Miskimen K, Main LR, Wang P, Liu Y, Moore N, Ogrocki P, Lerner AJ, Vance JM, Cuccaro ML, Haines JL, Pericak-Vance MA, Scott WK.   +24 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients. [PDF]

Oncogene
Andrieu C, Stoof J, AlSultan D, Ivers L, Berenguer Pina JJ, Skrobo D, Ballot J, O'Reilly D, Collins DM, Eustace AJ, Quinn C, Walshe JM, Gullo G, Walsh N, Crown J.   +14 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Bilateral renal and bladder agenesis with exceptional survival without prenatal intervention: a case report. [PDF]

Front Pediatr
Heyne-Pietschmann M, Caccia J, Tschumi S, Zeino M.   +3 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Understanding exceptional response: The role of MINDY1 SNP in CDK4/6 inhibitor therapy for ER⁺, HER2^- advanced breast cancer. [PDF]

HGG Adv
Balla E, Li Y, Zhou Z, Nguyen JT, Papadopoulou K, Razis E, Koutras A, Galani E, Mountzios G, Romanidou O, Fountzilas G, Christopoulou A, Tryfonopoulos D, Oikonomopoulou P, Saridaki Z, Koumarianou A, Fountzilas E, Bleris L.   +17 more
europepmc   +1 more source