Results 111 to 120 of about 6,991,423 (313)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Solving non-Hermitian physics for optical manipulation on a quantum computer

Light: Science & Applications
Intense laser light, with its ability to trap small particles, is providing us unprecedented access to the microscopic world. Nevertheless, owing to its open nature, optical force is nonconservative and can only be described by a non-Hermitian theory ...
Yu-ang Fan, Xiao Li, Shijie Wei, Yishan Li, Xinyue Long, Hongfeng Liu, Xinfang Nie, Jack Ng, Dawei Lu   +8 more
doaj   +1 more source

VERSAILLES, COMPIÈGNE ET FONTAINEBLEAU. À LA REDÉCOUVERTE D’UN PATRIMOINE THÉÂTRAL LONGTEMPS NÉGLIGÉ

In Situ
In France today, the only court theatres still in existence are at the royal palaces of Versailles, Compiègne and Fontainebleau. As heritage, they were neglected for a long time but are today the object of renewed interest. The stage sets which have been
Vincent Cochet, Étienne Guibert, Raphaël Masson   +2 more
doaj   +1 more source

The neolithic burials of Changis‑sur-Marne Les Pétreaux (Seine‑et‑Marne) in their regional context in the Paris Basin

Gallia Préhistoire, 2016
Between 1995 and 2004 quarrying by the aggregate extraction company Cemex over an area of seventy hectares in the double meander of Armentières upstream of Meaux provided an exceptional opportunity to investigate a site located in the floodplain of the ...
Jean‑Gabriel Pariat
doaj   +1 more source

Exceptional sets and Hilbert–Schmidt composition operators

Journal of Functional Analysis, 2003
Let \(D\) be the unit disk in the complex plane and \(\varphi\) be an analytic map from \(D\) to itself. Let \(E_\varphi = \{ e^{i\theta} \in \partial D : | \varphi(e^{i\theta})| = 1 \} \) be the exceptional set and the composition operator \(C_\varphi : {\mathcal{H}}(D) \rightarrow {\mathcal{H}}(D)\) be defined as \(C_\varphi f = f \circ \varphi ...
Gallardo-Gutiérrez, Eva A., González, Marı́a J.   +1 more
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Development of Aczel-Alsina t-norm based linear Diophantine fuzzy aggregation operators and their applications in multi-criteria decision-making with unknown weight information

Heliyon
Aczel-Alsina t-norm and t-conorm are intrinsically flexible and endow Aczel-Alsina aggregation operators with greater versatility and robustness in the aggregation process than operators rooted in other t-norms and t-conorm families. Moreover, the linear
Rizwan Gul, Tareq M. Al-shami, Saba Ayub, Muhammad Shabir, M. Hosny   +4 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Local cohomology along exceptional sets

Mathematische Annalen, 1986
Let \({\mathcal F}\) be a locally free coherent sheaf of a reduced complex space of dimension n. Let E be a closed analytic subset. To compute local cohomology along E one has natural homomorphisms \(H^ i_ E(X;{\mathcal F})\to \lim_{\to}Ext^ i_{{\mathcal O}_ X}({\mathcal O}_ X/{\mathcal J}^ m,{\mathcal F})\) and duality homomorphisms \(H^ i_ E(X ...
openaire   +1 more source