Results 81 to 90 of about 1,610,927 (333)
Does excess body weight accelerate immune aging?
Experimental GerontologyBackground: Overweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic inflammation and thus enhancing immunosenescence.
Anna Tylutka +3 more
doaj +1 more source
Евразийский Кардиологический Журнал, 2019 The purpose of this work is to analyze the daily levels of blood pressure and heart rate variability in patients with signs of metabolic syndrome.Materials and methods.
A. H. Mustafayeva
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Health care costs and lost productivity costs related to excess weight in Belgium [PDF]
, 2022 Vanessa Gorasso +7 more
openalex +1 more source
Entropy of polydisperse chains: solution on the Husimi lattice
, 2013 We consider the entropy of polydisperse chains placed on a lattice. In particular, we study a model for equilibrium polymerization, where the polydispersivity is determined by two activities, for internal and endpoint monomers of a chain.
Neto, Minos A., Stilck, Jürgen F.
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Understanding excess body weight: New Zealand Health Survey [PDF]
Explores the increase in obesity over a 36 year period to 2013 and investigates the impact of obesity on different birth cohorts. Summary Obesity is New Zealand’s leading modifiable risk factor for health loss.
Hilary Sharpe, Sarah Bradbury
core
Double Burden of Malnutrition Among Undergraduates in Ogun State Nigeria [PDF]
, 2015 Coexistence of under and over nutrition among the same population group is referred to as the double burden of malnutrition. The objective of this study was to assess double burden of malnutrition among undergraduate students in Ogun State Nigeria.
Ekerette, N. N. (Nkereuwem) +1 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source