Results 71 to 80 of about 1,068,314 (335)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Weight loss is a sufficient and economical single outcome measure of murine dextran sulfate sodium colitis

FASEB BioAdvances, 2019
Inflammatory bowel diseases (IBD: Crohn's disease and ulcerative colitis) are becoming common around the world without a cure. Animal models of colitis have become instrumental in IBD research.
Savini Lanka Britto, Mahesh Krishna, Richard Kellermayer   +2 more
doaj   +1 more source

Visceral adipose tissue adiponectin predicts excess weight loss after bariatric surgery in females with severe obesity [PDF]

, 2023
Giulia Cantini, Giovanni Quartararo, Niccolò Ghezzi, Diego Assis Gonçalves, Laura Fei, Arianna Pia Propato, Luca Galtarossa, Marcello Lucchese, Mario Maggi, Michaela Luconi   +9 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The effect of insulin on cardiac autonomic balance predicts weight reduction after gastric bypass [PDF]

, 2018
Aims/hypothesis: The aim of this study was to assess the predictive role of autonomic reactivity in body weight loss induced by gastric bypass. Methods: A group of 22 morbidly obese subjects, who were due to undergo a gastric bypass, were submitted ...
Assimacopoulos-Jeannet, F., Barthassat, V., Bobbioni-Harsch, E., Chassot, G., Golay, A., Huber, O., Lehmann, T., Morel, P., Sievert, K., Sztajzel, J.   +9 more
core  

Shame and self-acceptance in continued flux: qualitative study of the embodied experience of significant weight loss and removal of resultant excess skin by plastic surgery [PDF]

, 2012
This study explored the embodied experience of body change using a qualitative design. Eight previous plastic surgery patients of a London hospital took part in in-depth, semi-structured interviews 1 year post a plastic surgery procedure to remove excess
Smith, F., Farrants, J.R.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Determining the relationship of diet quality with weight change, body mass index, and depression in women who had undergone sleeve gastrectomy: A cross-sectional descriptive study

Revista Española de Nutrición Humana y Dietética, 2021
Introduction: This study aims to determine the relationship of diet quality in women with weight change, body mass index (BMI), and depression one year after undergoing sleeve gastrectomy.
Neslihan Ağbaba, Burcu Ateş Özcan, Gürdal Ören   +2 more
doaj   +1 more source

Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants [PDF]

, 2017
This is the final version of the article. Available from American Society for Nutrition via the DOI in this record.Background: For older groups, being overweight [body mass index (BMI; in kg/m(2)): 25 to
Bowman, K, Atkins, JL, Delgado, J, Kos, K, Kuchel, GA, Ble, A, Ferrucci, L, Melzer, D   +7 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source