Density-dependent effects on the survival and growth of the rodent stomach worm Protospirura muricola in laboratory mice [PDF]
, 2004 The spirurid nematode, Protospirura muricola, is of intrinsic interest as a rodent model of gastric nematode infections. Since worm burdens can be very heavy in nature, density dependent processes may constrain parasite growth. Laboratory mice (BKW) were
Behnke +10 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Single vs Repeated Treatment with the Intragastric Balloon: A 5-Year Weight Loss Study [PDF]
, 2018 Background: Saline-filled intragastric balloons (IB) may be inserted for 6months to promote weight loss. We aimed to assess potential benefits of repeating IB therapy. Methods: One hundred eighteen consecutive subjects (median body mass index, 34.0kg/m2;
Barea, Marie +5 more
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Influence of irrigation conditions in the germination of plasma treated Nasturtium seeds [PDF]
, 2018 Plasma treatments had emerged as a useful technique to improve seed germination. In this work we investigate the influence of different irrigation conditions and plasma treatments on the germination of nasturtium seeds.
Espinós Manzorro, Juan Pedro +5 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Variação do percentual da perda do excesso de peso no pós-operatório tardio dos pacientes obesos mórbidos submetidos ao bypass gastrointestinal em y de roux [PDF]
, 2010 Background: During follow-up in the late postoperative period of Roux-en-Y gastric bypass surgery (RYGBP), it is clinically demonstrated that many patients regain weight.
Barhouch, Anália Santiago
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Using maximum weight to redefine body mass index categories in studies of the mortality risks of obesity [PDF]
, 2014 BACKGROUND: The high prevalence of disease and associated weight loss at older ages limits the validity of prospective cohort studies examining the association between body mass index (BMI) and mortality.
Andrew Stokes
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Development of a Primary Care Clinician Intervention in the Management of Overweight and Obesity in Children and Adolescent: A Pound of Cure [PDF]
, 2011 Poster Division: Arts, Humanities, and Social Sciences: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Primary care clinicians, despite regular access to young families, lack a cohesive model for approaching office visits ...
Anzeljc, Samantha
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