Results 101 to 110 of about 6,354,037 (297)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Modeling and Analysis of Secure Ad Hoc Routing Protocol SRP

IEEE Access
Security analysis of ad hoc routing protocols in an adversarial environment is a challenging task. The paper utilizes Event-B to model and verify the Secure Routing Protocol (SRP), a secure on-demand source routing protocol.
Shicong Zhang, Chenhui Gu, Huanyu Zhou, Yisha Liu, Wanli Huo, Chunyan Fu, Zhaojuan Zhang   +6 more
doaj   +1 more source

Theory of barrier vs tilt exchange gate operations in spin-based quantum computing

, 2018
We present a theory for understanding the exchange interaction between electron spins in neighboring quantum dots, either by changing the detuning of the two quantum dots or independently tuning the tunneling barrier between quantum dots.
Shim, Yun-Pil, Tahan, Charles
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Multi-entity Behaviors in Electricity-Carbon-Green Certificate Coupled Markets Based on Multi-agent Reinforcement Learning

Zhongguo dianli
Establishing a national carbon emission trading market and green certificate market is one of the key strategies for China to achieve its "dual carbon" goals.
Feihang ZHOU, Hao WANG, Haili WANG, Meng WANG, Yaojie JIN, Zhongchun LI, Zhongde ZHANG, Peng WANG   +7 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Opinions on unbalanced funds in China’s electricity market

Frontiers in Energy Research, 2023
Jianing Zhu, Hao Yin, Yan Ma, Bo Sui, Mei Wang, Kaitao Yang   +5 more
doaj   +1 more source

A Concise History of Exchange Rate Regimes in Latin America [PDF]

This paper analyzes the experience of the major Latin American countries including Argentina, Brazil, Mexico, Colombia, Chile, Peru and others in the post-World-War period, up to the crisis caused by the collapse of the U.S. housing bubble.
Martín Rapetti, Roberto Frankel
core  

Custom, Contract, and Kidney Exchange [PDF]

, 2012
In this Essay, we examine a case in which the organizational and logistical demands of a novel form of organ exchange (the nonsimultaneous, extended, altruistic donor (NEAD) chain) do not map cleanly onto standard cultural schemas for either market or ...
Healy, Kieran, Krawiec, Kimberly D.
core   +2 more sources