Results 81 to 90 of about 2,370,040 (298)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Site Occupancy Preference and Magnetic Properties in Nd₂(Fe,Co)₁₄B

Crystals
Partial replacement of Fe by Co is an effective method to increase Curie temperature (TC), which improves the thermal stability of magnetic properties in Nd2Fe14B-based permanent magnets.
Xubo Liu, Ikenna C. Nlebedim
doaj   +1 more source

Non-Interactive Key Exchange [PDF]

, 2013
Non-interactive key exchange (NIKE) is a fundamental but much-overlooked cryptographic primitive. It appears as a major contribution in the ground-breaking paper of Diffie and Hellman, but NIKE has remained largely unstudied since then. In this paper, we provide different security models for this primitive and explore the relationships between them. We
Freire, E. S. V., Hofheinz, D., Kiltz, E., Paterson, K. G.   +3 more
openaire   +2 more sources

Effect of confinement potential shape on exchange interaction in coupled quantum dots

, 2007
Exchange interaction has been studied for electrons in coupled quantum dots (QD's) by a configuration interaction method using confinement potentials with different profiles.
A Kwaśniowski, Adamowski J, J Adamowski, Stopa M Marcus C M, Wang L Rastelli A Kiravittaya S Benyoucef M Schmidt O G, Zhang L-X Melnikov V Agarwal S Leburton J-P   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Mass modification of itinerant carriers in RKKY oscillations induced by finite range exchange interactions

, 2010
We investigate the Ruderman-Kittel-Kasuya-Yosida oscillations of the itinerant carrier spin density in a system where those oscillations appear only due to a finite distribution of a localized spin.
Smirnov, Sergey
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Quasi-particle interaction in nuclear matter from chiral pion-nucleon dynamics

, 2006
Based on a recent chiral approach to nuclear matter we calculate the in-medium interaction of nucleons at the Fermi surface $|\vec p_{1,2}|=k_f$.
Babu, Bogner, Bogner, Brown, Bäckman, Bäckman, Dabrowski, Dickhoff, Dickhoff, Entem, Entem, Epelbaum, Fritsch, Fritsch, Fritsch, Kaiser, Kaiser, Kaiser, Kaiser, Kaiser, Kaiser, Kuckei, Landau, Landau, Landau, Lutz, Migdal, N. Kaiser, Schwenk, Schwenk, Sjöberg, Wambach   +31 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source