Results 41 to 50 of about 7,524,478 (306)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Fixed Exchange Rate Regime or Floating Exchange Rate Regime?

open access: yesWorld Economic Research, 2016
论文介绍了IMF对汇率制度的分类,然后从可信度、平稳性、灵活性、货币政策独立性、金融危机等五个方面比较汇率制度的两极:固定汇率制度和浮动汇率制度的优点和缺点。我们发现没有一种汇率制度在所有时期适合所有国家,汇率制度的选择依赖于一国的具体条件。 In this paper, after introduce the classification of exchange rate regime by IMF, I compare the pros and cons of the two bipolar regimes: Fixed exchange rate regime and floating exchange rate regime in the aspect of reliability ...
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The Selection of Appropriate Foreign Exchange Rate Regime for Iranian Economy with Regards to Oil Shocks. [PDF]

open access: yesفصلنامه پژوهش‌های اقتصادی ایران, 2005
The main goal of this paper is to examine an appropriate exchange rate regime in Iran. Most of the studies in Iranian economy have suggested a flexible exchange rate regime with a coordination between monetary and exchange rate policies.
Akbar Komaijani, Mohammad Nad Ali
doaj  

The Interest Rate - Exchange Rate Nexus: Exchange Rate Regimes and Policy Equilibria [PDF]

open access: yesSSRN Electronic Journal, 2009
We study a credible Markov-perfect monetary policy in an open New Keynesian economy with incomplete financial markets. We demonstrate the existence of two discretionary equilibria. Following a shock the economy can be stabilised either 'quickly' or 'slow', both dynamic paths satisfy conditions of optimality and time-consistency.
Christoph Himmels, Tatiana Kirsanova
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Dynamics of a Floating Exchange Rate Regime [PDF]

open access: yesJournal of Political Economy, 1982
We study the full equilibrium dynamics of a two-country world economy with a floating exchange rate, traded and nontraded goods, and explicit modeling of the use of money. The resulting exchange rate equation depends on several details of the economic structure, such as the supply structure and propensities to spend on various goods.
Helpman, Elhanan, Razin, Assaf
openaire   +4 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

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