Results 41 to 50 of about 422,152 (298)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Macroeconomic Performance in Different Exchange Rate Regimes: An Estimated DSGE Approach [PDF]

Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2016
Selection of exchange rate regime and its consequences, is one of the major issues in international finance. Dependence of Iran to oil export revenues gives an important role to exchange rate policy in the economy.
Hossein Tavakolian, Vajihe Afzali Abarquyi   +1 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Volatilité des chocs et degré de flexibilité du taux de change [PDF]

Panoeconomicus, 2007
During the 90s emerging markets have been hit by recurrent exchange rate crises. Almost all these countries shared a common characteristic: they adopted in previous years soft pegs, the so-called intermediate exchange rate regimes.
Allegret Jean-Pierre, Ayadi Mohamed, Haouaoui Leila   +2 more
doaj   +1 more source

Classifying Exchange Rate Regimes [PDF]

, 2002
Isriya Nitithanprapas, Thomas D. Willett
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Mercosul: gainsfrom regional integration and exchange rate regimes

Economia Aplicada, 2002
This paper assesses the impacts of the Mercosul Preferential Trade Agreement on Brazil's regions and their industries between 1990 and 2000 by means of a gravity model, extended to include dummy variables for Mercosul, for a Brazilian region and for a ...
Paulo C. de Sá Porto, Otaviano Canuto
doaj  

Exchange Rate Regimes and Financial Sector Stability in Nigeria

Journal of Accounting and Finance in Emerging Economies
Purpose: This paper examined the role of exchange rate regimes in the stability of the financial sector in Nigeria, on the context of a long standing exchange rate volatility and the frequency of the exposure of the banking sector in an oil-intensive ...
Kayode David Kolawole
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source