Results 51 to 60 of about 2,333,541 (344)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Modeling and Forecasting Exchange Rates

open access: yesLithuanian Journal of Statistics, 2016
This paper investigates models for the euro exchange rate against the currencies of Denmark, Poland, theUnited States, and the United Kingdom. The objective of this paper is to compare different methods of modeling andout-of-sample forecasting.
Jovita Gudan
doaj   +1 more source

An explicit UK policy for a lower exchange rate will not boost economic growth as some have suggested [PDF]

open access: yes, 2012
Philip Booth argues that lower exchange rates is not the solution for the problem of stimulating economic growth in the UK. It is real exchange rates that determine the cost of exports and imports relative to alternatives, and, since the UK can only ...
Booth, Philip
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Exchange rates and national income

open access: yesPSL Quarterly Review, 2014
The devaluations of September 1949 have revived active controversies in the field of international trade theory. In the course of these discussions certain aspects of the problem hitherto but little considered have been focussed and a special emphasis ...
T. BALOGH, P. STREETEN
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Currency Wars: What do effective exchange rates tell us? [PDF]

open access: yes
In November, South Korea joined the ranks of countries striving to limit the upwards pressure on their currency when two lawmakers submitted a parliamentary proposal to impose various taxes on foreign capital inflows and outflows.
Christophe Gouardo, Jean Pisani-Ferry
core   +1 more source

Effective Exchange Rates in Japan, 1879-1938 [PDF]

open access: yes, 2004
This paper constructs nominal and real multilateral effective exchange rates ffor Japan during the period 1879-1938. Existing studies of Japanese quantitative economic history have tended to use the dollar-yen bilateral exchange rate.
Shimazaki, Masao, Solomou, Solomos
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

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