Results 81 to 90 of about 24,702 (281)

Comparisons Between Frequency Distributions Based on Gini’s Approach: Principal Component Analysis Addressed to Time Series

Econometrics
In this paper, time series of length T are seen as frequency distributions. Each distribution is defined with respect to a statistical variable having T observed values.
Pierpaolo Angelini
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Towards a Multi-Subject Analysis of Neural Connectivity [PDF]

, 2014
Directed acyclic graphs (DAGs) and associated probability models are widely used to model neural connectivity and communication channels. In many experiments, data are collected from multiple subjects whose connectivities may differ but are likely to ...
da Costa, Lilia Carneiro, Nichols, Tom, Oates, Chris J.   +2 more
core  

A note on the exchangeability condition in Stein's method

, 2008
We show by a surprisingly simple argument that the exchangeability condition, which is key to the exchangeable pair approach in Stein's method for distributional approximation, can be omitted in many standard settings.
Adrian Röllin, Barbour, Barbour, Chatterjee, Diaconis, Fulman, Fulman, Rinott, Röllin   +8 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Aging Renewal Point Processes and Exchangeability of Event Times

Mathematics
In this paper, we investigate the impact of latency aging on exchangeable (invariant under permutation of indices) inter-arrival times arising from mixed renewal point processes (statistical mixtures of point processes with renewal inter-arrival times ...
Fabio Vanni, David Lambert
doaj   +1 more source

Predictive verification for the design of partially exchangeable multi-model ensembles

Tellus: Series A, Dynamic Meteorology and Oceanography, 2020
The performance of an ensemble forecast, as measured by scoring rules, depends on its number of members. Under the assumption of ensemble member exchangeability, ensemble-adjusted scores provide unbiased estimates of the ensemble-size effect.
Zied Ben Bouallégue, Christopher A. T. Ferro, Martin Leutbecher, David S. Richardson   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Horizon-Independent Optimal Prediction with Log-Loss in Exponential Families

, 2013
We study online learning under logarithmic loss with regular parametric models. Hedayati and Bartlett (2012b) showed that a Bayesian prediction strategy with Jeffreys prior and sequential normalized maximum likelihood (SNML) coincide and are optimal if ...
Bartlett, Peter, Grunwald, Peter, Harremoes, Peter, Hedayati, Fares, Kotlowski, Wojciech   +4 more
core